ATV 20

Indications of ATV 20

When diet and other non-pharmacological approaches fail to lower increased total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglyceride levels in the following conditions, atorvastatin is prescribed as an adjuvant to diet.

• To lower total cholesterol and LDL cholesterol in patients with familial hypercholesterolemia, both heterozygous and homozygous.
• To treat patients with combined dyslipidemia who have high cholesterol and triglycerides (Fredrickson Type Ia and Ib).
• For the treatment of hypertriglyceridemia patients with increased blood triglyceride levels (Fredrickson Type IV).

 

Pharmacology of ATV 20

• Dysbetalipoproteinemia (Dysbetalipoproteinemia) is treated with this drug (Fredrickson Type III).
• Reduce myocardial ischemic episodes in people with asymptomatic or mild to moderately symptomatic coronary artery disease and high LDL cholesterol levels.
• Patients with hypercholesterolemia caused or exacerbated by diabetes mellitus or renal transplantation should have their total and LDL cholesterol levels reduced.

 

Dosage & Administration

Primary hypercholesterolaemia and combined hyperlipidaemia-

• Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to max. 80 mg once daily.
• Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 20 mg once daily.

Familial hypercholesterolaemia-

• Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolaemia).
• Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 80 mg once daily.

Prevention of cardiovascular events-

• Adults: Initially 10 mg once daily adjusted according to response.

 

Interaction of ATV 20

Concurrent use of cyclosporin, fibric acid derivatives, erythromycin, azole antifungals, and niacin increases the risk of myopathy while taking Atorvastatin. When Atorvastatin was used with antihypertensives or hypoglycemic medications, no clinically meaningful interactions were seen. If Atorvastatin is used with digoxin, erythromycin, oral contraceptives, colestipol, antacid, or warfarin, patients should be continuously watched.

 

Contraindications

Patients who are hypersensitive to any component of atorvastatin should avoid taking it. Active liver disease or unexplained chronic transaminase increases are contraindicated with ATV 20. It's also not recommended for patients who have had a significant reaction to HMG-CoA reductase inhibitors in the past.

 

Side Effects of ATV 20

ATV 20 is well tolerated by most people. Constipation, flatulence, dyspepsia, and abdominal pain are the most common ATV 20 side effects. Infection, headache, back pain, rash, asthenia, arthralgia, and myalgia are some of the other side effects.

 

Pregnancy & Lactation

Pregnancy: ATV 20 is contraindicated amid pregnancy. Security in pregnant ladies has not been built up. No controlled clinical trials with ATV 20 have been conducted in pregnant ladies. Uncommon reports of intrinsic irregularities taken after the intrauterine presentation to HMG-CoA reductase inhibitors have been gotten. The creature thinks about have appeared harmfulness to propagation. Maternal treatment with atorvastatin may decrease the fetal levels of mevalonate which may be an antecedent of cholesterol biosynthesis. ATV 20 ought to not be used in ladies who are pregnant, attempting to end up pregnant, or suspect they are pregnant. Treatment with atorvastatin ought to be suspended for the length of pregnancy or until it has been decided that the lady isn't pregnant

It is unknown whether ATV 20 or its metabolites are excreted in human milk during lactation. The amounts of atorvastatin and its active metabolites in rats' plasma are similar to those found in milk. Breastfeeding is not recommended for women taking atorvastatin because of the risk of major side effects. Taking ATV 20 while nursing is not recommended.

 

Precautions & Warnings

Effects on the liver: Liver function tests should be done before starting treatment and then on a regular basis after that. In patients who drink a lot of alcohol or have a history of liver illness, ATV 20 should be administered with caution. If severely raised CPK levels or myopathy is diagnosed or suspected, ATV 20 medication should be stopped.

 

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins.

 

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

 

Pharmaceutical Name of ATV 20

Delta Pharma Ltd

 

Generic of ATV 20

Atorvastatin Calcium

 

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