Cardon 25

Generic

Losartan Potassium

 

Indications

Hypertension: Losartan Potassium is demonstrated for the treatment of hypertension. It may be utilized alone or in combination with other antihypertensive operators (eg. thiazide diuretics). Renal Assurance in Type-2 Diabetic Patients with Proteinuria: Losartan Potassium is demonstrated to delay the movement of renal malady in hypertensive type-2 diabetics with proteinuria, characterized as urinary egg whites to creatinine proportion >300 mg/g

 

Pharmacology

Losartan Potassium is the primary non-peptide orally dynamic angiotensin II receptor blocker. It ties to the AT1 receptor found in numerous tissues (e.g. vascular smooth muscle, adrenal organ, kidneys and the heart) and diminishes a few critical natural activities counting vasoconstriction and the discharge of aldosterone mindful for hypertension.

 

Dosage & Administration

The normal beginning and upkeep measurement is 50 mg once day by day for most patients. In case the antihypertensive impact utilizing 50 mg once every day is lacking, 25 mg twice every day is suggested earlier to expanding the measurements. For patients with intravascular volume depletion (e.g., those treated with high-dose diuretics), beginning measurements of 25 mg once day by day ought to be considered. Losartan Potassium can be managed once or twice every day. The whole day-by-day dosage ranges from 25 mg to 100 mg.

 

Interaction

Rifampicin and fluconazole diminish levels of dynamic metabolite of Losartan Potassium. Concomitant utilize of Losartan Potassium and hydrochlorothiazide may lead to potentiation of the antihypertensive impacts. Concomitant utilize of potassium-sparing diuretics (eg, spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increments in serum potassium. The antihypertensive impact of losartan may be weakened by the non-steroidal anti-inflammatory medicate indomethacin. The utilize of ACE-inhibitor, angiotensin receptor opponent, an anti-inflammatory medicate, and a thiazide diuretic at the same time increments the chance of renal impedance.

 

Contraindications

Losartan Potassium is contraindicated in pregnant ladies and in patients who are extremely touchy to any component of this item. Losartan Potassium ought to not be managed with Aliskiren in patients with diabetes.

 

Side Effects

The negative effects of Losartan Potassium are minor and only last a short time. Dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection are the most prevalent adverse effects. Fatigue, edema, stomach pain, chest pain, nausea, headache, and pharyngitis are some of the other side effects.

 

Pregnancy & Lactation

Pregnancy Category D. The chance to the baby increments on the off chance that Losartan Potassium is managed amid the moment or third trimesters of pregnancy. It isn't known whether Losartan Potassium is excreted in the human brain, as numerous drugs are excreted in the human drain and since of the potential for unfavorable impacts on the nursing newborn child, a decision should be made whether to suspend nursing or suspend the medicate, taking into consideration the significance of the medicate to the mother.

 

Precautions & Warnings

Utilize of Losartan Potassium amid the moment and third trimesters of pregnancy decreases fetal renal work and increments fetal and neonatal horribleness and passing. In patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics), symptomatic hypotension may happen. The plasma concentration of Losartan Potassium is altogether expanded in cirrhotic patients. Changes in renal work counting renal disappointment have been detailed in renal disabled persistent.

 

Therapeutic Class

Angiotensin-ll receptor blocker

 

Storage Conditions

Keep away from light and heat in a dry location. Keep out of children's reach.

 

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.