Flugal 50 Capsule
by Square Pharmaceuticals Limited
৳8.07
Square Pharmaceuticals Limited
Fluconazole
Fluconazole is indicated for the treatment of vaginal candidiasis, oropharyngeal and esophageal candidiasis, and Curiputococcal meningitis. It is also effective in the treatment of urinary tract infections caused by Candida peritonitis, systemic candidiasis (candidiasis, disseminated candidiasis, pneumonia, etc.).
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of cytochrome P450-dependent fungal enzymes. The cytochrome P450 enzyme system is an essential component of fungal cell membranes, responsible for the synthesis of ergosterol.
Adult (oral)-
Vaginal candidiasis: 150 mg as a single dose.
Oropharyngeal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of this infection generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse.
Esophageal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used. Patients should be treated for a minimum of three weeks and for at least two weeks following resolution of symptoms.
Systemic candida infections: Optimal therapeutic dosage and duration of therapy have not been established. Sometimes, doses of up to 400 mg daily have been used.
Urinary tract infections caused by candida and peritonitis: 50-200 mg daily have been used.
Cryptococcal meningitis: 400 mg on the first day, followed by 200 mg once daily.
Prophylaxis in patients undergoing bone marrow transplantation: 400 mg once daily.
Child (oral):
Doses of 3-6 mg/kg daily have been used. Doses up to 12 mg/kg is recommended.
Intravenous-
Adult: Invasive candidal infections including candidaemia and disseminated candidiasis and cryptococcal infections including meningitis, by IV, 400 mg initially then 200 mg daily, increased if necessary to 400 mg daily, treatment continued according to response (at least 6-8 weeks for cryptococcal meningitis)
Child: 6-12 mg/kg daily (every 72 hours in neonate up to 2 weeks old, every 48 hours in neonate 2-4 weeks old); maximum 400 mg daily. Prevention of relapse of cryptococcal meningitis, by IV, 100-200 mg daily.
Concomitant use of ciclosporin or phenytoin with fluconazole increases plasma concentrations of ciclosporin or phenytoin. Concomitant use of fluconazole and warfarin prolongs prothrombin time. Rifampicin levels are reduced when used with fluconazole.
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Fluconazole is well tolerated. Most common side effects of using Fluconazole includes nausea, vomiting, abdominal pain, diarrhoea, headache and skin rash.
The US FDA Pregnancy Category for fluconazole is C. Therefore, fluconazole should be avoided during pregnancy and lactation, unless the potential benefits to the other type outweigh those possible risk to the fetus.
Fluconazole should be administered with caution to patients having proarrhythmic conditions.
Drugs for subcutaneous and mycoses
Keep in a dry place away from light and heat. Keep out of the reach of children.
Square Pharmaceuticals Ltd.
by Renata Pharma Ltd
৳8.04