Comet 500 Tablet
by Square Pharmaceuticals Limited
৳5.00
Aristopharma Ltd.
Metformin Hydrochloride.
Treatment of type 2 diabetes mellitus, particularly in overweight patients when dietary management and exercise alone do not result in adequate glycemic control.
A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure.
Metformin could be a biguanide sort verbal antihyperglycemic medicate utilized within the administration of sort 2 diabetes. It brings down both basal and postprandial plasma glucose. Its instrument of activity is distinctive from those of sulfonylureas and it does not create hypoglycemia. Metformin diminishes hepatic glucose generation, diminishes intestinal assimilation of glucose, and makes strides affront affectability by an increment in fringe glucose take-up and utilization.
Metformin immediate-release tablet: Dosage of Metformin Hydrochloride must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily doses.
Metformin extended-release tablet: Swallow Metformin XR tablet whole and never crush, cut or chew.
Carbonic anhydrase (Topiramate, Zonisamide) co-administration may raise the risk of lactic acidosis. Drugs that inhibit Metformin clearance (Ranolazine, Dolutegravir, Cimetidine) may cause Metformin buildup. Metformin's effect on lactate metabolism can be amplified by alcohol.
Blood and lymphatic system disorders: Not known: Hemolytic anemia
Metabolism and nutrition disorders: Very rare: Lactic acidosis. Decrease of vitamin B12 absorption with a decrease of serum levels during long-term use of metformin. Consideration of such etiology is recommended if a patient presents with megaloblastic anemia. Cases of peripheral neuropathy in patients with vitamin B12 deficiency have been reported in post-marketing experience (frequency not known)
Nervous system disorders: Common: Taste disturbance. Not known: Encephalopathy
Gastrointestinal disorders: Very common: Gastrointestinal disorders, such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These undesirable effects occur most frequently during the initiation of therapy and resolve spontaneously in most cases. To prevent them, it is recommended that metformin be taken in 2 or 3 daily doses during or after meals. A slow increase of the dose may also improve gastrointestinal tolerability.
Hepatobiliary disorders: Very rare: Isolated reports of liver function test abnormalities or hepatitis resolving upon metformin discontinuation.
Skin and subcutaneous tissue disorders: Very rare: Skin reactions, such as erythema, pruritus, urticaria.
Pregnancy: Uncontrolled diabetes amid pregnancy (gestational or lasting) is related to an expanded hazard of inherent anomalies and perinatal mortality. When the persistent plans to end up pregnant and amid pregnancy, it is prescribed that diabetes isn't treated with metformin but insulin be utilized to preserve blood glucose levels as near to typical as conceivable, to diminish the hazard of distortions of the fetus.
Breastfeeding: Metformin is excreted into the human breast drain. No antagonistic effects were watched in breastfed newborns/infants. Be that as it may, as only restricted information is accessible, breastfeeding isn't prescribed amid metformin treatment. A decision on whether to discontinue breastfeeding ought to be made, taking into consideration the good thing about breastfeeding and the potential hazard to antagonistic impacts on the child.
Metformin Hydrochloride is known to be eliminated in large amounts through the kidneys, and the danger of Metformin buildup and lactic acidosis increases as renal function declines. Metformin has been linked to a reduction in vitamin B12 levels. When combined with insulin or an insulin secretagogue, it raises the risk of hypoglycemia.
Biguanides.
Keep the temperature below 30°C and keep it away from light and moisture. Keep out of children's reach.
Aristopharma Ltd.
by Incepta Pharmaceuticals Ltd
৳6.00