Glucozid 80

Generic

Gliclazide.

 

Indications

Patients with maturity-onset diabetes mellitus (NIDDM) who require an oral hypoglycaemic medication should use gliclazide.

 

Pharmacology

Gliclazide is a sulfonylurea of the second generation with hypoglycemic and perhaps hematological effects. It reduces hepatic glucose output while stimulating insulin release from pancreatic -cells by promoting Ca+2 transport across the -cell membranes.

 

Dosage & Administration

Film-coated tablet: The regular introductory dosage is 40 to 80 mg every day. The measurements can be expanded up to 320 mg day by day in separated measurements when required. The medicate ought to be taken some time recently dinner. For children, Gliclazide isn't utilized since it is contraindicated in juvenile-onset diabetes. Modified discharge planning: The regular day-by-day dose for Gliclazide 30 mg is 1 to 4 tablets & Gliclazide 60 mg is 1 to 2 tablets per day as a single measurement. It is suggested that the senate ought to be taken at breakfast time. It is best to require this sedate before breakfast in arrange to dodge or to play down the conceivable onset of stomach-related clutters.

 

Interaction

The hypoglycemic impacts of Gliclazide may be expanded by Ibuprofen, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal specialists, and Monoamine Oxidase inhibitors. The hypoglycemic impact of Gliclazide a few times may be diminished by Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic drugs, and every so often Liquor.

 

Contraindications

Gliclazide should not be used in -

• Juvenile-onset (type-1) diabetes
• Diabetes associated with Ketosis
• Diabetic patients undergoing surgery, after severe injury or during infection
• Patients having hypersensitivity for sulfonylurea group of drugs
• Pregnant women and breastfeeding mothers
• Hepatic insufficiency

 

Side Effect

Hypoglycemia can occur in the presence of other illnesses such as hepatic and renal dysfunction, starvation, and alcohol consumption. Headaches, gastrointestinal problems, nausea, dizziness, and skin reactions such as rash, pruritus, and erythema are all possible side effects.

 

Pregnancy & Lactation

Pregnant women should avoid taking gliclazide. It should not be used by a mother who is breastfeeding.

 

Precautions & Warnings

Gliclazide ought to be utilized carefully in patients with hepatic disabilities. On the off chance that there's a clear hepatic malady at that point, gliclazide ought to not be utilized. Gliclazide can be utilized securely in patients with renal lacking because it is broadly metabolized. Gliclazide has less sudden hypoglycemic scene than other sulfonylurea gathers of drugs.

 

Therapeutic Class

Sulfonylureas.

 

Storage Conditions

Keep the temperature below 30°C and keep it away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name

Aristopharma Ltd.