Lacitone 20

Generic

Furosemide + Spironolactone

Indications

Lacitone is indicated for -

• Essential hypertension
• Congestive heart failure
• Liver cirrhosis with ascites
• Swelling due to excess fluid retention (edema)
• Hyperaldosteronism

Pharmacology

Spironolactone (potassium-sparing diuretic) and furosemide (loop diuretic) have different but complementary mechanisms and sites of action. Therefore, when they are administered together, they will produce an additional or synergistic diuretic. The furosemide component inhibits the Na+/K+/2Cl cotransporter in the Henlesheng ring and blocks the reabsorption of sodium, potassium, and chloride ions; thereby increasing the amount of sodium and water excreted in the urine. This characteristically leads to potassium loss. The spironolactone component inhibits the reabsorption of potassium by sodium in the distal tubules by antagonizing the effect of aldosterone, thereby greatly increasing sodium excretion and reducing excessive potassium loss caused by furosemide.

Dosage & Administration

1 to 4 tablets daily, (20 to 80 mg of Furosemide and 50 to 200 mg of Spironolactone) according to patient's response.

Interaction

Drug interaction may occur with the following drugs: ACE inhibitors, potassium salts, Cardiac glycosides, Corticosteroids, NSAIDs.

Contraindications

Lacitone is contraindicated in patient with hyperkalemia, hyponatremia, acute renal insufficiency and hypersensitivity to Furosemide or to Spironolactone or to any ingredient containing this product.

Side Effects

Fatigue, nausea, malaise, gastric upset, headache, hypotension, skin rash.

Pregnancy & Lactation

Lacitone should be used with caution during pregnancy and only if expected benefit to mother is greater than the possible risk to the fetus. Furosemide passes into breast milk. It's not recommended while breast feeding.

Precautions & Warnings

Electrolyte imbalance should be monitored. Special precaution should be taken in patients of diabetes, prostatic hypertrophy, hypotension, hypovolemia.

Therapeutic Class

Potassium-sparing diuretics, Potassium-sparing diuretics & Aldosterone antagonists

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Pharmaceutical Name

General Pharmaceuticals Ltd.