Mebiz SR

Generic

Mebeverine Hydrochloride

 

Indications

Mebeverine is indicated for the:

• Symptomatic treatment of irritable bowel syndrome (IBS)
• Chronic irritable colon
• Spastic constipation
• Mucous colitis
• Colicky abdominal pain
• Persistent non-specific diarrhoea

 

Pharmacology

Pharmacodynamics: Mechanism of Action and Pharmacodynamic Effects: Mebiz SR is a musculotropic antispasmodic with a direct effect on the smooth muscle of the gastrointestinal tract, relieving spasm without affecting normal gut motility. Since this effect is not mediated by the autonomic nervous system, the typical anticholinergic side effects are absent.

Pharmacokinetics: Absorption: Mebiz SR is rapidly and completely absorbed after oral administration. The modified-release formulation permits a twice-daily dosing scheme.

Distribution: No significant accumulation occurs after multiple doses.

Biotransformation: Mebiz SR is mainly metabolized by esterases, which split the ester bonds into veratric acid and Mebiz SR alcohol firstly.

 

Dosage & Administration

For adults, elderly and children over 10 years:

• Mebeverine Hydrochloride 135 mg tablet: 1 tablet 03 times daily.
• Mebeverine Hydrochloride 200 mg capsule: 1 capsule 02 times daily.

This is most effective when taken 20 minutes before meals. After several weeks when the desired effect has been obtained, the dosage may be gradually reduced.

Missed dose: If a dose of this medicine is missed, that should be taken as soon as possible. However, if it is almost time for the next dose, then skip the missed dose and the regular dosing schedule should be maintained. Dose should not be doubled at the same time to compensate the missed dose.

Use in children: Mebeverine is not recommended for children under 10 years.

 

Interaction

No interaction studies have been performed except with alcohol. In vitro and in vivo studies in animals have demonstrated the absence of any interaction between Mebiz-SR and ethanol.

 

Contraindications

Hypersensitivity to the drug or any other ingredients.

 

Side Effects

Generally Mebeverine is well tolerated. However, few side-effects like skin rash, urticaria and angioedema may appear.

 

Pregnancy & Lactation

In animal studies, there has been no evidence of teratogenicity. However, standard precautions should be followed while administering any medicine during pregnancy. After receiving a therapeutic dose of mebeverine, it is not excreted in breast milk.

 

Precautions & Warnings

Caution should be exercised in porphyria or allergic reaction to this or any other medicine of this group.

 

Therapeutic Class

Anticholinergics.

 

Storage Conditions

Store at a cool temperature (not exceeding 25°C) and dry place, protected from light.

 

Pharmaceuticals name

Sun Pharmaceutical Ltd.