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Flunarizine
The difluorinated derivative of cinnarizine is flunarizine. It is a calcium channel antagonist that is selective. Calcium transmembrane inflow is reduced by lowering excessive calcium transmembrane influx. Flunarizine prevents calcium excess in cells. It has no effect on normal calcium homeostasis in cells. Flunarizine also possesses calming and antihistaminic effects. It binds to plasma protein with a 99 percent affinity.
Migraine Prophylaxis:
Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required.
Vertigo & motion sickness: 10-20 mg daily for adults and 5 mg daily for children (> 40 kg).
Epileptic seizure: 15-20 mg daily in adults and 5 to 10 mg daily for children as an add-on therapy
Galactorrhoea has been recorded in a small number of women taking oral contraceptives during the first two months of treatment with Flunarizine. Carbamazepine and phenytoin, both hepatic enzyme inducers, may interact with flunarizine by increasing its metabolism. As a result, an increase in flunarizine dosage may be necessary.
Hypersensitivity to Flunarizine. Flunarizine is contra-indicated in patients with a history of depressive illness, or with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.
Weight gain and/or increased hunger may occur, as well as drowsiness and/or exhaustion. During long-term Flunarizine use, the following side effects have been reported: Extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which older patients appear to be more at risk; depression, of which female patients with a history of depressive disease may be particularly at risk. Heartburn, nausea, gastralgia, sleeplessness, anxiety, galactorrhoea, dry mouth, muscle discomfort, and skin rash are some of the less commonly reported side effects.
Safety in pregnancy and lactation has not been established.
Flunarizine may cause sleepiness, which is exacerbated if alcohol or other central nervous system depressants are consumed at the same time. Patients should be warned against driving or undertaking other potentially dangerous jobs when a loss of mental attention could result in an accident. Flunarizine isn't recommended for stopping a migraine. The possibility of an attack is consequently no cause to raise Flunarizine dosage. This medication may cause extrapyramidal and depressive symptoms, as well as disclose Parkinsonism, particularly in people who are prone to it, such as the elderly. In such patients, flunarizine should be taken with caution.
Miscellaneous prophylactic migraine preparations
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Opsonin Pharma Ltd.
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