Naprox 500

Indications of Naprox 500

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis, and acute gout are among the conditions for which naproxen is prescribed. It's also used to treat pain and dysmenorrhea in women with primary dysmenorrhea.

 

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.

 

Pharmacology

Naproxen is an anti-inflammatory, analgesic, and antipyretic non-steroidal anti-inflammatory medication (NSAID). It is quickly absorbed from the gastrointestinal system and has a bioavailability of 95%.

 

Dosage & Administration of Naprox 500

Naproxen Tablet-

• Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis: The usual dose is 500-1000 mg daily in two divided doses after meals.
• Management of pain, primary dysmenorrhea, acute tendonitis & bursitis: Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg.
• Acute gout: Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided.

Naproxen Suspension-

• For Juvenile rheumatoid arthritis: The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hours intervals. Therapy in children under 2 years of age is not recommended.

Naproxen Gel-

• Is to be applied 2-6 times a day as required and is not recommended for use in children.

 

Interaction of Naprox 500

ACE inhibitors: diminish the antihypertensive effect of ACE inhibitors.
Antacids & Sucralfate: delay the absorption of Naproxen.
Aspirin: increase adverse effects.
Diuretics: reduce the natriuretic effect of Furosemide and Thiazides.
Methotrexate: enhance the toxicity of Methotrexate.
Warfarin: increase the risk of GI bleeding.
Selective Serotonin Reuptake Inhibitors (SSRI): increase the risk of GI bleeding.

 

Contraindications

Patients who have a known hypersensitivity to naproxen should avoid using it. Patients who have had asthma, urticaria, or allergic-type responses after taking aspirin or other NSAIDs should not use it. In the situation of coronary artery bypass graft (CABG) surgery, it is contraindicated for the management of perioperative discomfort.

 

Side Effect

The following are the most often reported adverse effects:

• Heartburn, stomach discomfort, nausea, diarrhea, and dyspepsia are all symptoms of gastrointestinal problems.
• Headache, vertigo, and sleepiness are symptoms of the Central Nervous System.
• Pruritus (itching) and purpura are two dermatological conditions.
• Edema and palpitation are symptoms of cardiovascular disease.
• Other symptoms include visual and auditory problems.

 

Pregnancy & Lactation

Naproxen is classified as a pregnancy category C by the US Food and Drug Administration. So, unless the potential advantages to the other outweigh the potential dangers to the unborn, Naproxen should be avoided during pregnancy and breastfeeding.

 

Therapeutic Class

Non-steroidal anti-inflammatory drugs, drugs for osteoarthritis, drugs for rheumatoid arthritis (NSAIDs)

 

Storage Conditions

Keep it below 30°C. Do not allow yourself to get frozen.

 

Generic Name of Naprox 500

Naproxen Sodium