Omenix 40

Generic

Omeprazole

Indications

Omeprazole is shown for the treatment of- 

Pharmacology

Omeprazole, a substituted benzimidazole, is an inhibitor of gastric corrosive emission. It represses gastric corrosive emission by blocking hydrogen-potassium-adenosine triphosphatase (H+ /K+ ATPase) chemical framework within the gastric parietal cell. After verbal organization, the onset of the antisecretory effect happens inside one hour, with the most extreme effect occurring inside two hours and hindrance of emission lasts up to 72 hours. When the medicate is ceased, secretory activity returns continuously, over 3 to 5 days.

Dosage

Oral-

• Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration; in severe or recurrent cases, dose to be increased to 40 mg daily; maintenance dose for recurrent duodenal ulcer, 20 mg once daily; in prevention of relapse in duodenal ulcer, 10-20 mg daily.
• NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks, if not fully healed. 20 mg once daily is used as prophylaxis in patients with a history of NSAID-associated duodenal or gastric ulcers.
• Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks, if not fully healed; 40 mg once daily has been given for 8 weeks in gastro-esophageal reflux disease, refractory to other treatment; maintenance dose is 20 mg once daily.
• Long-term management of acid reflux disease: 10-20 mg daily.
• Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks.
• Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery.
• Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily (If daily dose is more than 80 mg, 2 divided dose should be used).
• Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents as detailed below: Amoxicillin 500 mg and Metronidazole 400 mg both three times a day for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice a day for one week, or Amoxicillin 1 g and Clarithromycin 500 mg both twice a day for one week.
• Paeditaric use in severe ulcerating reflux esophagitis (Child>1 year): If body-weight 10-20 kg, 10-20 -mg once daily for 4-12 weeks; if body-weight over 20 kg, 20-40 mg once daily for 4-12 weeks.

IV Injection-

• Prophylaxis of acid aspiration: Omeprazole 40 mg to be given slowly (over a period of 5 minutes) as an intravenous injection, one hour before surgery.
• Duodenal ulcer, gastric ulcer or reflux oesophagitis: In patients with duodenal ulcer, gastric ulcer or reflux oesophagitis where oral medication is inappropriate, Omeprazole IV 40 mg once daily is recommended.
• Zollinger- Ellison syndrome (ZES): In patients with Zollinger-Ellison Syndrome the recommended initial dose of Omeprazole given intravenously is 60 mg daily. Higher daily doses may be required and the dose should be adjusted individually. When doses exceed 60 mg daily, the dose should be divided & given twice daily.

Direction for use of IV Injection: Omeprazole lyophilized powder and water for injection is for intravenous administration only and must not be given by any other route. Omeprazole IV injection should be given as a slow intravenous injection. The solution for IV injection is obtained by adding 10 ml water for injection to the vial containing powder. After reconstitution the injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute. Use only freshly prepared solution. The solution should be used within 4 hours of reconstitution.

Direction for use of IV Infusion: Omeprazole IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more. The contents of one vial must be dissolved in 100 ml saline for infusion or 100 ml 5% Dextrose for infusion. The solution should be used within 12 hours when Omeprazole is dissolved in saline and within 6 hours when dissolved in 5% Dextrose. The reconstituted solution should not be mixed or co-administered in the same infusion set with any other drug.

Interaction

Omeprazole can draw out the disposal of diazepam, warfarin and phenytoin. So, lessening of warfarin or phenytoin dosage may be vital when Omeprazole is added to the treatment. There's no prove of an interaction of Omeprazole with theophylline, propranolol or antacids

Contraindications

Omeprazole is contraindicated in patients with known hypersensitivity to any of the components of the definition

Side Effects

Omeprazole is for the most part well endured. Sickness, abdominal colic, paresthesia, discombobulation and migraine have been stated to be by and large mellow and transitory and not requiring a reduction in dose

Pregnancy & Lactation

US FDA pregnancy category of Omeprazole is C. However, results from three imminent epidemiological studies indicate no antagonistic impacts of Omeprazole on pregnancy or on the wellbeing of the fetus/newborn child. There's no information accessible on the section of Omeprazole into breast drain or its impacts on the neonate. Breast-feeding should, hence, be suspended, in case the utilize of Omeprazole is considered basic.

Precautions & Warnings

When gastric ulcer is suspected, the plausibility of gastric malignancy ought to be avoided some time recently treatment with Omeprazole is organizations, as treatment may reduce the symptoms and delay determination.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry put absent from light and warm. Keep out of the reach of children.

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.