Opsonil 50

Indications of Opsonil 50

Chlorpromazine is indicated in Psychoses, Nausea and vomiting, Psychoses, Intractable hiccup, Psychoses.

 

Pharmaceutical Name of Opsonil 50

Opsonin Pharma Ltd.

 

Pharmacology

Chlorpromazine is a neuroleptic that acts by blocking the postsynaptic dopamine receptor in the mesolimbic dopaminergic system and inhibits the release of hypothalamic and hypophyseal hormones. It has antiemetic, serotonin-blocking, and weak antihistaminic properties and slight ganglion-blocking activity.

 

Dosage & Administration

Oral: Psychoses:

• Adult: 25 mg tid; may be given as a single 75 mg dose at night. Maintenance: 25-100 mg tid increased to ≥1 g daily as required in psychotic patients.
• Child: 1-12 yr: 500 mcg/kg every 4-6 hr. Max: >5 yr: 75 mg daily; 1-5 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

Oral: Intractable hiccup:

• Adult: Initially, 25-50 mg 3-4 times daily for 2-3 days; if unresponsive, may admin 25-50 mg via IM inj. If still necessary, 25-50 mg in 500-1000 ml of normal saline may be given via slow IV infusion.
• Child: 1-12 yr: 500 mcg/kg every 4-6 hr. Max: >5 yr: 75 mg daily; 1-5 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

Intramuscular: Psychoses:

• Adult: 25-50 mg repeated every 6-8 hr. Substitute with oral therapy as soon as possible.
• Child: 1-12 yr: 500 mcg/kg every 4-6 hr. Max: >5 yr: 75 mg daily; 1-5 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

Intramuscular: Nausea and vomiting:

• Adult: Initially, 25 mg via IM inj, followed by 25-50 mg every 3-4 hr until vomiting stops.
• Child: 1-12 yr: 500 mcg/kg every 4-6 hr. Max: >5 yr: 75 mg daily; 1-5 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

 

Interactions of Opsonil 50

Interactions Resulting in Decreased Chlorpromazine Concentrations: Food, alcohol and benztropine may decrease absorption of chlorpromazine. Antacids can slow the absorption of chlorpromazine. Lithium and chronic use of barbiturates may lead to increased clearance of chlorpromazine. 
Interactions Leading to Increased Chlorpromazine Concentrations: Tricyclic antidepressants reduce the clearance of chlorpromazine and may cause increased serum concentrations. Administration of chlorpromazine with CYP1A2 inhibitors, either particularly strong (such as ciprofloxacin and fluvoxamine) or moderately (such as oral contraceptives and vemurafenib) resulted in increased plasma concentrations of chlorpromazine. As a result, patients may experience side effects dependent on chlorpromazine.

 

Contraindications

Hypersensitivity; preexisting CNS depression, coma, bone-marrow supression; phaeochromocytoma; lactation.

 

Side-Effects of Opsonil 50

Tardive dyskinesia (on long-term therapy). Involuntary movements of extremities may also occur. Dry mouth, constipation, urinary retention, mydriasis, agitation, insomnia, depression and convulsions; postural hypotension, ECG changes. Allergic skin reaction, amenorrhoea, gynaecomastia, weight gain. Hyperglycaemia and raised serum cholesterol.

 

Pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

 

Precautions

Parkinson's disease; CV disease; renal or hepatic impairment; cerebrovascular and respiratoty disease; jaundice; DM; hypothyroidism; paralytic ileus; prostatic hyperplasia or urinary retention; epilepsy or history of seizures; myasthenia gravis; pregnancy; elderly (especially with dementia), and debilitated patients. Avoid direct sunlight.

 

Therapeutic Class

Anti-emetic drugs, Phenothiazine drugs, Phenothiazine related drugs

 

Storage Conditions

Store at 15-30°C.

 

Generic of Opsonil 50

Chlorpromazine Hydrochloride