Stafen

Generic

Ketotifen Fumarate.

 

Indications

Ketotifen is indicated in the following conditions-

• For the prophylactic treatment of bronchial asthma.
• Symptomatic treatment of allergic conditions including rhinitis and conjunctivitis.
• For alleviating the complications of itching, pain, and tenderness associated with neurofibroma.
• Symptomatic treatment of allergy such as high fever, urticaria.

 

Pharmacology

Ketotifen has anti-allergic properties and has been utilized so also, to sodium cromoglycate within the prophylactic treatment of asthma. It too has the properties of an antihistamine. Ketotifen has stamped anti-anaphylactic properties and is compelling in anticipating an asthmatic assault. Ketotifen applies as the supported inhibitory impact on histamine responses, which can be clearly separated from its anti-anaphylactic properties. Test examinations in asthmatic subjects have appeared that Ketotifen is as viable orally as a particular pole cell stabilizer managed by inward breath. Antihistamines were incapable in those tests. The adequacy of Ketotifen has been examined in long-term clinical trials. Asthma assaults were diminished in number, seriousness, and term, and in a few cases, the patients were totally liberated from assaults. Dynamic decrease of corticosteroids and/or bronchodilators was too conceivable.

 

Dosage & Administration

Adults: 1 mg twice daily with food. If necessary, the dose may be increased to 2 mg twice daily in severe cases.

Children above 3 years: 1 mg twice daily with food. Patients known to be easily sedated should begin treatment with 0.5 to 1 mg at night for the first few days or as directed by the physician.

Use in elderly: Same as adult dose or as advised by the physician.

 

Interaction

Sedatives, hypnotics, antihistamines, and alcohols may be amplified by ketotifen. A reversible decrease in platelet count has been documented in a few patients taking Tifen with oral antidiabetic medications, leading to the recommendation that this combination is avoided.

 

Contraindications

A reversible drop within the platelet number has been watched in many patients getting Ketotifen concomitantly with a verbal antidiabetic operator and it has been recommended that this combination ought to hence be maintained a strategic distance from. In spite of the fact that there's no proof of any teratogenic impact, suggestions for Ketotifen in pregnancy or when breast nourishing cannot be given.

 

Side Effect

Laziness and in separated cases, dry mouth and slight tipsiness may happen at the starting of treatment but as a rule, vanish suddenly after a number of days.

 

Pregnancy & Lactation

Ketotifen is not indicated during pregnancy or lactation, despite the lack of evidence of teratogenic effects.

 

Precautions & Warnings

It is vital to proceed with the past treatment for a least two weeks after beginning Ketotifen to dodge the plausibility of worsening of asthma. This applies extraordinarily to systemic corticosteroids and ACTH since the conceivable presence of adrenocortical is inadequate in steroid subordinate understanding. In case associate current contamination happens, Ketotifen treatment must be supplemented by a particular antimicrobial treatment. Amid the primary day of treatment with Ketotifen, responses may be disabled and patients should be cautioned not to require a charge of vehicle or apparatus until the impact of Ketotifen treatment on the person is known. Patients ought to be exhorted to dodge alcoholic drinks. Ketotifen may potentiate the impacts of narcotics, hypnotics, antihistamines, and liquor.

 

Therapeutic Class

Cromoglycate and related medications.

 

Storage Conditions

Protect from light and store in a cool, dry location. Keep out of children's reach.

 

Pharmaceutical Name

Aristopharma Ltd.