Veserc 16

Indications of Veserc 16 Tablet

Meniere's illness and Meniere-like syndromes are characterized by vertigo, tinnitus, and/or progressive hearing loss, sometimes accompanied by nausea and vomiting.

 

Pharmacology of Veserc 16 Tablet

Betahistine has a multifaceted method of action. Meniere's illness is thought to be caused by a breakdown in the ear's endolymphatic fluid equilibrium. Betahistine is primarily an agonist for the histamine H1 receptor. The stimulation of H1-receptors in the inner ear generates a vasodilatory effect in the blood vessels, resulting in enhanced permeability and a reduction in endolymphatic pressure; this action prevents the rupture of the labyrinth, which can contribute to Ménière's disease hearing loss. Betahistine is also thought to relieve symptoms of vertigo by minimizing asymmetrical functioning of sensory vestibular organs and boosting vestibulocochlear blood flow.

In addition to the aforementioned processes, betahistine functions as a histamine H3-receptor antagonist, increasing histamine turnover from postsynaptic histaminergic nerve receptors and, as a result, enhancing H1-agonist activity. H3-receptor antagonism raises levels of neurotransmitters in the brainstem, particularly serotonin, which inhibits vestibular nuclei activity, restoring normal balance and reducing vertigo symptoms.

 

Dosage & Administration of Veserc 16 Tablet

The usual initial dose: 8 mg to 16 mg three times daily taken preferably with meals.

Maintenance dose: Up to 48 mg daily has been recommended. Betahistine is not recommended for use in children.

 

Interaction of Veserc 16 Tablet

There have been no documented occurrences of dangerous interactions. Although a potential antagonism between Betahistine and antihistamines should be expected, no such interactions have been documented.

 

Contraindications

In pheochromocytoma, betahistine is not recommended.

 

Side Effects of Veserc 16 Tablet

Betahistine is generally well tolerated, and no major side effects have been reported. Gastrointestinal problems, headaches, rashes, and pruritus have all been reported in rare cases.

 

Pregnancy & Lactation

In Pregnancy: Although there is no known teratogenic impact in animals, the safety of Betahistine in human pregnancy has not been fully proven. Before administering Betahistine during pregnancy, it's important to weigh the potential advantages carefully.

Betahistine is excreted in similar amounts in the breast milk of nursing mothers as it is in the plasma. The neonate's toxicity at these amounts is unknown.

 

Precautions & Warnings

Patients with bronchial asthma and peptic ulcer disease should be cautious.

 

Therapeutic Class

Meniere's disease medications

 

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name of Veserc 16 Tablet

UniMed UniHealth Pharmaceuticals Ltd

 

Generic of Veserc 16 Tablet

Betahistine Dihydrochloride