Adam 33 (5)

Generic

Prednisolone

 

Indications

Rheumatic Disorders: Psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis.

Endocrine Disorders: Primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, nonsuppurative thyroiditis, hypercalcemia associated with cancer.

Dermatologic Diseases: Pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme, exfoliative dermatitis, mycosis fungoides, severe psoriasis.

Allergic States: Seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, drug hypersensitivity reactions.

Respiratory Diseases: Symptomatic sarcoidosis, berylliosis, fulminating, aspiration pneumonitis.

Hematologic Disorders: Idiopathic thrombocytopenic purpura, secondary thrombocytopenia, acquired (autoimmune) hemolytic anemia, erythroblastopenia (RBC anemia).

Edematous States: To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.

Gastrointestinal Diseases: Ulcerative colitis, regional enteritis.

 

Pharmacology

To learn more about Prednisolone, please visit its official website. Because of this, it has a direct inhibitory effect on the phospholipase A2, which is responsible for producing leukotransmitters and other inflammatory mediators, such as prostaglandin A and SRS-A. Oral prednisolone is swiftly and efficiently absorbed from the GI tract. 70-90 percent of prednisolone is protein-bound in the plasma, and it is removed from the plasma with a half-life of two to four hours. Most of it is broken down in the liver and eliminated in the urine.

 

Dosage and Administration

Adult-
Nephrotic Syndrome:

• Initial: 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
• Maintenance dose: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.

Anti-inflammatory: 5 to 60 mg per day in divided doses 1 to 4 times/day.

Acute Asthma: 40-60 mg/day PO in single daily dose or divided q12 hr for 3-10 days.

Allergic Conditions:

• Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime.
• Day 2: 5 mg PO before breakfast, after lunch, and after dinner and 10 mg at bedtime.
• Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime.
• Day 4: 5 mg PO before breakfast, after lunch, and at bedtime.
• Day 5: 5 mg PO before breakfast and at bedtime.
• Day 6: 5 mg PO before breakfast.

Pediatric-
Asthma:

• 1 year: Acute: 10 mg orally every 12 hours. Maintenance: 10 mg orally every other day.
• 1 to 4 years: Acute: 20 mg orally every 12 hours. Maintenance: 20 mg orally every other day.
• 5 to 12 years: Acute: 30 mg orally every 12 hours. Maintenance: 30 mg orally every other day.
• 12 years: Acute: 40 mg orally every 12 hours. Maintenance: 40 mg orally every other day.

Anti-inflammatory: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Immunosuppression: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

 

Interaction

Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone, and Rifampin all impair the efficacy of prednisolone's effects. In the blood, prednisolone decreases potassium levels. If hypokalemia occurs, digitalis can cause cardiac arrhythmias. Immunization should be done with great caution.

 

Contraindications

Unless appropriate anti-infective therapy is used, systemic infections will occur. Intolerance to a single component. Ocular herpes simplex because of the possibility of perforation

 

Side Effects

Other common adverse effects include a greater desire to consume food and a feeling of anxiousness or restlessness. Skin darkening or lightening, dizziness or lightheadedness, flushing of the face or cheeks, hiccups, increased sweating, and the sense of spinning are less common or rare adverse effects.

 

Pregnancy & Lactation

Not suggested for usage during pregnancy, unless your doctor feels it is absolutely necessary. However, it should be used only if the projected benefit to a mother outweighs any possible harm to the foetus. These hormones are found in breast milk and may inhibit growth, interfere with the body's own corticosteroid synthesis, and have other undesirable consequences on the baby's development.

 

Precautions & Warnings

If you have diabetes or hypertension or are pregnant or have chronic nephritis, you should proceed with caution. This drug can lead to Cushing's syndrome, hyperglycemia, muscle weakness and a greater susceptibility to infection.

 

Therapeutic Class

Glucocorticoids

 

Storage Conditions

Store in a cool and dry place, protected from light. Keep out of the reach of the children.

 

Pharmaceutical Name

Nuvista Pharma Ltd.