Deltasone 5

Generic

Prednisolone

 

Indications

Rheumatic diseases: psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute and subacute bursitis, nonspecific acute tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis. 

Endocrine diseases: primary or secondary adrenal insufficiency, congenital adrenal hyperplasia, non-suppurative thyroiditis, hypercalcemia associated with cancer. 

Skin diseases: pemphigus, bullous dermatitis, severe erythema multiforme, exfoliative dermatitis, mycosis fungoides, severe psoriasis. 

Allergic status: seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, allergic drug reaction. 

Respiratory diseases: symptomatic sarcoidosis, beryllium poisoning, fulminant, aspiration pneumonia. 

Hematological diseases: idiopathic thrombocytopenic purpura, secondary thrombocytopenia, acquired hemolytic anemia (autoimmune), erythrocytopenia (erythrocytic anemia). 

Edema state: used for diuretic or proteinuria in nephrotic syndrome, without uremia, idiopathic or lupus erythematosus. 
Gastrointestinal diseases: ulcerative colitis, regional enteritis.

 

Pharmacology

Prednisolone is a synthetic adrenal cortex drug similar to glucocorticoids. Prednisolone inhibits phospholipase A2, which is responsible for the production of inflammatory mediators such as leukotrienes, SRSA and prostaglandins. After oral administration, prednisolone is rapidly and completely absorbed from the gastrointestinal tract. The protein binding rate of prednisolone in plasma is 70% to 90%, and it has a half-life of 2 to 4 hours before being cleared. It is mainly processed in the liver and excreted in urine.

 

Dosage & Administration

Adult-

Nephrotic Syndrome:

• Initial: 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
• Maintenance dose: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.
• Anti-inflammatory: 5 to 60 mg per day in divided doses 1 to 4 times/day.

Acute Asthma: 40-60 mg/day PO in single daily dose or divided q12 hr for 3-10 days.

Allergic Conditions:

• Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime.
• Day 2: 5 mg PO before breakfast, after lunch, and after dinner and 10 mg at bedtime.
• Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime.
• Day 4: 5 mg PO before breakfast, after lunch, and at bedtime.
• Day 5: 5 mg PO before breakfast and at bedtime.
• Day 6: 5 mg PO before breakfast.

Pediatric-

Asthma:

• 1 year: Acute: 10 mg orally every 12 hours. Maintenance: 10 mg orally every other day.
• 1 to 4 years: Acute: 20 mg orally every 12 hours. Maintenance: 20 mg orally every other day.
• 5 to 12 years: Acute: 30 mg orally every 12 hours. Maintenance: 30 mg orally every other day.
• 12 years: Acute: 40 mg orally every 12 hours. Maintenance: 40 mg orally every other day.

Anti-inflammatory: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Immunosuppression: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

 

Interaction

Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone, and Rifampin all impair the efficacy of prednisolone. Prednisolone lowers potassium levels in the blood. If hypokalemia occurs, digitalis can cause cardiac arrhythmias. Immunization should be done with extreme caution.

 

Contraindications

Unless appropriate anti-infective therapy is used, systemic infections will occur. Any component can cause hypersensitivity. Because of the possibility of perforation, ocular herpes simplex.

 

Side-Effects

Common side effects include increased appetite, indigestion, nervousness, or restlessness. Rare or rare side effects are darkening or lightening of the skin, dizziness or dizziness, flushing of the face or cheeks, hiccups, increased sweating, and a spinning sensation.

 

Pregnancy & Lactation

Unless the doctor considers it essential, it is not recommended to use this medicine during pregnancy. It should only be used when the expected benefit to the mother exceeds any possible risks to the fetus. Corticosteroids appear in breast milk and may inhibit growth, interfere with the production of endogenous corticosteroids, or cause other adverse effects.

 

Precautions & Warnings

Preventive measures should be taken for diabetes, hypertension, psychological disorders, osteoporosis, postmenopausal women, pregnancy and chronic nephritis. Long-term use of prednisolone can cause Cushing's habituation, hyperglycemia, muscle weakness, increased susceptibility to infection, delayed wound healing, and mental disorders.

 

Therapeutic Class

Glucocorticoids

 

Storage Conditions

Store in a cool and dry place, protected from light. Keep out of the reach of the children.

 

Pharmaceutical Name

Renata Limited