Azithromax 500

Generic

Azithromycin Dihydrate

 

Indications

Azithromycin is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, in otitis media, and in the skin and soft tissue infections.

 

Pharmacology

Azithromycin is acid-stable and can therefore be taken orally with no need for protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. The time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and high lipid solubility.

 

Dosage & Administration

Azithromycin should be taken at least 1 hour before or 2 hours after a meal.

 

Interactions

Azithromycin absorption is reduced in presence of food and antacid.

 

Contraindications

Azithromycin is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic.

 

Side Effects

Azithromycin is well tolerated with a low incidence of side effects. The side effects include nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhea, headache, dizziness, and skin rashes and are reversible upon discontinuation of therapy.

 

Pregnancy & Lactation

The pregnancy Category of Azithromycin is B. Animal reproduction studies have demonstrated that Azithromycin has no evidence of harm to the fetus. There are no adequate and well-controlled studies in pregnant women.

 

Precautions & Warnings

As with any antibiotic, observation for signs of superinfection with non-susceptible organisms, including fungi, is recommended. No dose adjustment is needed in patients with renal impairment.

 

Therapeutic Class

Macrolides

 

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

 

Pharmaceutical Name

Ziska Pharmaceuticals Ltd.