Calchek 5

Indications of Calchek 5mg Tablet

Calchek 5mg Tablet is effective as a monotherapy in the treatment of essential hypertension. It can be combined with other antihypertensive medications.

Angina pectoris: Calchek 5mg Tablet is an effective monotherapy for the treatment of chronic stable angina pectoris. It can be combined with other antianginal medications.

Vasospastic angina: Calchek 5mg Tablet is used to treat vasospastic angina that has been verified or suspected. It can be used alone or in conjunction with other antianginal medications.

 

Pharmacology of Calchek 5mg Tablet

Amlodipine is a calcium-channel blocker that is used to treat hypertension and angina pectoris. It is a dihydropyridine calcium-channel blocker with a long half-life. Amlodipine affects myocardial cells, cells in the heart's specialized conducting system, and cells in the vascular smooth muscle. Amlodipine causes vasodilation, which results in lower peripheral resistance, blood pressure, and afterload, as well as enhanced coronary blood flow and a reflex rise in coronary heart rate. As a result, myocardial oxygen supply and cardiac output both rise.

 

Calchek 5mg Tablet Dosage & Administration

Hypertension: Usual dose is 5 mg once daily. The maximum dose is 10 mg once daily. Elderly patients with hepatic insufficiency may be started on 2.5 mg once daily; this dose may also be used when adding Amlodipine to other antihypertensive therapy.

Angina (Chronic stable or Vasospastic): 5 to 10 mg, using the lower dose for elderly and in patients with hepatic insufficiency. Most patients require 10 mg.

Administrations: May be taken without regard to meals.

 

Interaction of Calchek 5mg Tablet

Drug Interactions-

• Potentially hazardous interactions: Little or no data are available in patients with markedly impaired cardiac left ventricular function; however, as with other calcium antagonist drugs, the combination of Amlodipine and p-blockers should be avoided in such patients.

Other Significant Interactions-

• Digoxin: Absence of any interaction between Amlodipine and Digoxin in healthy volunteers has been documented in a controlled clinical study.
• Cimetidine: An unpublished clinical study indicated no interaction between, Amlodipine and Cimetidine in healthy volunteers.
• Warfarin: An unpublished clinical study in healthy volunteers indicates that Amlodipine did not significantly alter the effect of Warfarin on prothrombin time.
• Food: Food does not alter the rate or extent of absorption of Amlodipine.

 

Contraindications of Calchek 5mg Tablet

Hypersensitivity to dihydropyridine derivatives. Pregnant woman.

 

Calchek 5mg Tablet Side Effects

Calchek 5mg Tablet's most common side effects are dizziness, flushing, headache, hypotension, and peripheral edema, all of which are caused by its vasodilatory action. GI issues, increased micturition frequency, fatigue, eye pain, and mental distress are all possible side effects. At the onset of treatment, a paradoxical rise in ischemic chest discomfort may occur, and in a few patients, an extreme drop in blood pressure has resulted in cerebral or myocardial ischemia or transitory blindness. Rashes, fever, and changes in liver function may arise as a result of an Amlodipine hypersensitivity reaction.

 

Pregnancy & Lactation

Pregnancy Classification C. Amlodipine has not been studied in pregnant women in a sufficient and well-controlled manner. Only if the possible benefit outweighs the risk to the fetus should amlodipine be used during pregnancy. Amlodipine is not known to be excreted in human milk. Nursing should be stopped while Amlodipine is being delivered in the absence of this information.

 

Precautions & Warnings

Precaution should be taken in patients with hepatic impairment and during pregnancy and breastfeeding.

 

Therapeutic Class

Calcium-channel blockers

 

Storage Conditions

Keep all medicines out of reach of children. Store in a cool & dry place, protected from light.

 

Pharmaceutical Name of Calchek 5mg Tablet

General Pharmaceuticals Ltd

 

Generic

Amlodipine Besilate

 

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