Bizoran 5/20 Tablet
by Beximco Pharmaceuticals Ltd.
৳12.00
Calnor 5/20
Opsonin Pharma Limited
1 Strip = 14 Pcs
৳168.00
1 Box = 3 Strips
৳504.00
Dosage: Amlodipine 5mg, Olmesartan Medoxomil 20mg
Form: Tablet
Generic name(s): Amlodipine 5mg, Olmesartan Medoxomil 20mg
Available (pcs): 0
Prescription required: No
Calnor 5/20 Tablet: View Uses, Side Effects, Price - osudpotro
Calnor 5/20 tablet which Generic is Olmesartan Medoxomil 20mg + Amlodipine 5mg. Calnor 5/20 Tablet is indicated for the treatment of hypertension, alone or with other antihypertensive agents. Calnor 5/20 Tablet may also be used as initial therapy in patients who are likely to need multiple antihypertensive agents to achieve their blood pressure goals.
Indications of Calnor 5/20 Tablet
Calnor 5/20 Tablet is indicated for the treatment of hypertension, alone or with other antihypertensive agents. Calnor 5/20 Tablet may also be used as initial therapy in patients who are likely to need multiple antihypertensive agents to achieve their blood pressure goals.
Pharmacology of Calnor 5/20 Tablet
Amlodipine is a dihydropyridine calcium channel blocker that prevents calcium ions from crossing the blood-brain barrier and entering vascular smooth muscle and cardiac muscle. Compared to cardiac muscle cells, amlodipine has a stronger effect on vascular smooth muscle cells. Amlodipine is a peripheral artery vasodilator that reduces peripheral vascular resistance and blood pressure by acting directly on vascular smooth muscle.
Angiotensin II is a powerful vasoconstrictor, the principal vasoactive hormone of the Renin-angiotensin system, and an essential component in the pathogenesis of hypertension. It is generated from angiotensin I in a mechanism catalyzed by angiotensin-converting enzyme (ACE). It also causes the adrenal cortex to secrete more aldosterone.
By specifically blocking angiotensin II's binding to the AT1 receptor located in numerous tissues, Olmesartan Medoxomil reduces the vasoconstrictor and aldosterone-secreting effects of angiotensin II (e.g. vascular smooth muscle, adrenal gland). Olmesartan Medoxomil is a reversible, competitive AT1 receptor inhibitor, according to in vitro binding tests.
Calnor 5/20 Tablet Dosage & Administration
General considerations
Maximum antihypertensive effects are attained within 2 weeks. Calnor 5/20 Tablet may be administered with other antihypertensive agents. Dosage may be increased after 2 weeks. The maximum recommended dose of Calnor 5/20 Tablet is 2 tablets (10/40 mg) once daily.
Initial therapy
The usual starting dose of Calnor 5/20 Tablet is one tablet (5/20 mg) once daily. Depending on the blood pressure response, the dose may be titrated at intervals of 1-2 weeks to two tablets (10/40 mg) once daily.
Replacement therapy
Calnor 5/20 Tablet may be substituted for its individually titrated components. When substituting for individual components, the dose of one or both of the components can be increased if blood pressure control has not been satisfactory.
Add-on Therapy
Calnor 5/20 Tablet may be used to provide additional blood pressure lowering for patients not adequately controlled with Amlodipine (or another dihydropyridine calcium channel blocker) alone or with Olmesartan Medoxomil (or another Angiotensin receptor blocker) alone.
Elderly patients
No dosage adjustment is necessary in elderly patients ≥ 65 years age.
Patients with hepatic impairment Initial therapy with Calnor 5/20 Tablet is not recommended in patient’s ≥75 years and in patients with hepatic impairment.
Interaction of Calnor 5/20 Tablet
In vitro data indicate that Amlodipine has no effect on the human plasma protein binding of digoxin, phenytoin, warfarin, and indomethacin. No significant drug interactions were reported when Olmesartan was co-administered with digoxin or warfarin.
Contraindications of Calnor 5/20 Tablet
Calnor 5/20 Tablet is contraindicated in patients who are hypersensitive to any component of this product or to any of its ingredients.
Calnor 5/20 Tablet Side Effects
The overall incidence of side effects on therapy with Calnor 5/20 Tablet was similar to that seen with corresponding doses of the individual components and to placebo. The common side effects include edema, hypotension, orthostatic hypotension, rash, pruritus, palpitation, urinary frequency, and nocturia.
Pregnancy and Lactation
Olmesartan medoxomil: Pregnancy Categories C (first trimester) and D (second and third trimesters). Amlodipine: There are no adequate and well-controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. When pregnancy is detected, discontinue this Calnor 5/20 Tablet as soon as possible. It is not known whether the Amlodipine or Olmesartan Medoxomil is excreted in human milk.
Precautions & Warnings
Caution should be exercised in patients with volume or salt depletion, severe aortic stenosis,severe obstructive coronary artery disease, congestive heart failure, impaired renal function, and hepatic impairment. No initial dosage adjustment is recommended for patients with moderate to marked renal impairment (Creatinine clearance).
Therapeutic Class of Calnor 5/20 Tablet
Combined antihypertensive preparations
Storage Conditions
Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.
Pharmaceutical Name
Generic
Amlodipine Besilate + Olmesartan Medoxomil
