Olmezest AM 20

Indications of Olmezest AM 20 Tablet

To reduce blood pressure, it's used to treat hypertension alone or in combination with other antihypertensive drugs. This combination medicine is recommended as the first treatment for individuals who are likely to require numerous antihypertensive medications to reach their blood pressure objectives. Considerations such as baseline blood pressure, the objective goal, and the incremental chance of attaining a goal with a combination vs monotherapy should all be considered when deciding whether to employ a combination as initial therapy. Depending on the patient's risk, blood pressure targets may differ.

Pharmacology of Olmezest AM 20 Tablet

Amlodipine is a dihydropyridine calcium channel blocker that prevents calcium ions from crossing the blood-brain barrier and entering vascular smooth muscle and cardiac muscle. Compared to cardiac muscle cells, amlodipine has a stronger effect on vascular smooth muscle cells. Amlodipine is a peripheral artery vasodilator that reduces peripheral vascular resistance and blood pressure by acting directly on vascular smooth muscle.

Angiotensin II is a strong vasoconstrictor, the major vasoactive hormone of the Renin-angiotensin system, and a key component in the pathogenesis of hypertension. It is produced from angiotensin I in a process catalyzed by angiotensin-converting enzyme (ACE).

Olmezest AM 20 Tablet Dosage & Administration

Substitute individually titrated components for patients on Amlodipine and Olmesartan Medoxomil. This combination may also be given with increased amounts of Amlodipine, Olmesartan Medoxomil, or both, as needed.

Initial therapy: Initiate with 5/20 mg once daily for 1 to 2 weeks and titrate as needed up to a maximum of 10/40 mg once daily. Due to decreased clearance of Amlodipine among elderly patients the recommended starting dose of Amlodipine is 2.5 mg in patients 75 years. The lowest dose of the combination is 5/20 mg; therefore, initial therapy with this combination drug is not recommended in patients >75 years old.

Interactions of Olmezest AM 20 Tablet

NSAIDs such as selective COX-2 inhibitors may reduce the antihypertensive impact of angiotensin II receptor antagonists like Olmesartan Medoxomil. In patients receiving combination treatment or other drugs that impact the RAS, blood pressure, renal function, and electrolytes should be carefully monitored.

Contraindications of Olmezest AM 20 Tablet

Cannot be co-administered with Aliskiren in patients with diabetes.

Olmezest AM 20 Tablet Side Effects

Peripheral edema, headache, flushing, and dizziness are the most frequent adverse effects. It can also induce sprue-like enteropathy, which is a type of intestinal disease.

Pregnancy & lactations

D is the pregnancy category. The combination of amlodipine and olmesartan medoxomil should not be taken in the second or third trimester since it might cause fetal mortality. This combination should be stopped as soon as possible if pregnancy is found. Olmesartan and Amlodipine are not known to be excreted in human milk. Because of the risk of harm to the nursing child, a choice should be taken on whether to stop breastfeeding or stop taking the medicine, taking into account the drug's value to the mother.

Precautions & warnings

Because of the potential of hypotension in volume- or salt-depleted individuals, the combination of Amlodipine and Olmesartan Medoxomil should be taken with care.

Patients with severe aortic stenosis benefit from vasodilation.

Angina or acute Ml with a higher frequency, length, or severity in individuals with significant obstructive coronary artery disease.

Therapeutic Class of Olmezest AM 20 Tablet

Combined antihypertensive preparations

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.

Pharmaceutical Name of Olmezest AM 20 Tablet

Sun Pharmaceutical Ltd

Generic

Amlodipine Besilate + Olmesartan Medoxomil

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