Cef-3 DS 400 Mg

Indications

Upper and lower respiratory tract infections, Urinary tract infections, Gonococcal urethritis, Acute otitis media.

 

Pharmacology

Cefixime is a third-era semisynthetic cephalosporin anti-infection for the oral organization. It is bactericidal against an expansive range of gram-positive and gram-negative microorganisms at an effectively feasible plasma focus. It kills microbes by meddling in the combination of bacterial cell dividers. It is profoundly steady within the sight of the Beta-lactamase chemical. Accordingly, numerous life forms impervious to penicillin and some cephalosporins because of the presence of beta-lactamases, might be powerless to Cefixime. Retention of it is about 40% to half whether directed with or without food.

 

Dosage & Administration

The typical treatment period is seven days. Depending on the severity of the infection, this can be done for up to 14 days.

Adults and children over the age of 12: The recommended should take 200-400 mg (1 to 2 capsules) every day, either in one dose or in two divided doses. A single oral dose of Cefixime 400 mg is suggested for the treatment of uncomplicated cervical/urethral gonococcal infections.

Children (6 months or older): Usually 8 mg/kg/day given as a single dose or in two divided doses or may be given as follows

• ½-1 year: 75 mg daily.
• 1-4 years: 100 mg daily.
• 5-10 years: 200 mg daily.
• 11-12 years: 300 mg daily
• In typhoid fever, the dosage should be 10 mg/kg/day for 14 days.

Children (under 6 months): Cefixime's safety and efficacy in children less than 6 months have not been established.

 

Interaction

Carbamazepine: Taking these drugs together raises the carbamazepine level. Concurrent use of warfarin and other anticoagulants raises prothrombin time.

 

Contraindications

Patients with Known hypersensitive to the cephalosporin group of drugs.

 

Side Effects

In general, the medication is well tolerated. Diarrhea and stool alterations are the most common adverse effects, which are more typically associated with greater doses. Nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache, and dizziness are some of the other side effects. Rashes, pruritus, urticaria, drug fever, and arthralgia have all been described as allergic reactions. These reactions normally fade away after a while.

 

Pregnancy & Lactation

However, no suitable and well-controlled studies in pregnant women have been conducted. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Cefixime is not known to be excreted in human milk. When Cefixime is given to a breastfeeding mother, caution should be observed.

 

Precautions & Warnings

Individuals having a history of gastrointestinal disorders, particularly colitis, should be prescribed with caution. Patients with severe renal impairment, as well as those on continuous ambulatory peritoneal dialysis or hemodialysis, should be given the medicine with caution. Only in severe renal failure (creatinine clearance 20 ml/min) does dosage adjustment become necessary.

 

Therapeutic Class

Cephalosporins of the third generation

 

Storage Conditions

Keep the temperature below 30°C and keep it away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name

Square Pharmaceuticals Ltd.

 

Generic

 

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