Cialix 10

Generic

Indications

Tadalafil is prescribed in-

• ED is an abbreviation for Erectile Dysfunction (ED)
• Benign Prostatic Hyperplasia (BPH) is a kind of benign prostatic hyperplasi (BPH)
• Erectile Dysfunction as well as the indications and symptoms of Benign Prostatic Hyperplasia
• Hyperplasia

Pharmacology

Tadalafil is a PDE5 (phosphodiesterase type 5) inhibitor. PDE5 inhibition raises cGMP levels in smooth muscle cells. cGMP relaxes smooth muscles and increases blood flow to the corpus cavernosum, resulting in penile erection. PDE5 is also found in the smooth muscles of the prostate and bladder wall. Inhibiting PDE5 raises cGMP concentrations, resulting in smooth muscle relaxation in the prostate and bladder. Smooth muscle relaxation may increase blood flow to the urinary system and enlarge the aperture of the bladder neck, resulting in more efficient voiding.

Dosage & Administration

Interaction

Isosorbide, Nitroglycerin, Alpha adrenergic blockers, Antihypertensives, Alcohol, Antacids (magnesium hydroxide/aluminum hydroxide), Ketoconazole, Ritonavir, Erythromycin, Itraconazole, Grapefruit juice, other HIV protease inhibitors, Rifampin, Carbamazepine, Phenytoin, and Phenobarbital may interact

Contraindications

• Use of Nitrates (for example, Nitroglycerine, Isosorbide): Nitrates' hypotensive effects may be exacerbated.
• Tadalafil hypersensitivity reactions

Side Effects

Common side effects include headache, dyspepsia, back discomfort, myalgia, nasal pharyngitis, and nasal congestion. Changes in color vision, sudden vision loss, hearing loss, Stevens-Johnson Syndrome, exfoliative dermatitis, angina, stroke, myocardial infarction, severe hypotension, and tachycardia are all possible complications.

Pregnancy & Lactation

The USFDA has classified tadalafil as pregnancy category B. Tadalafil should only be used during pregnancy if the benefits exceed the risks. There is no information about Tadalafil excretion in human milk. When giving tadalafil to a breastfeeding woman, exercise extreme caution.

Precautions & Warnings

Angina, renal impairment, hepatic impairment, and bleeding when using Nitrates, Alpha Blockers, Alcohol, CYP3A4 Inhibitors (such as Ritonavir, Ketoconazole, and Itraconazole), and other PDE5 inhibitors should all be avoided.

Therapeutic Class

Storage Conditions

Store in a cool, dry area away from light and heat. Keep out of children's reach.

Pharmaceutical Name