Tadalis 10

Generic

Tadalafil

 

Indications

• Erectile Dysfunction is a condition for which Tadalafil is prescribed (ED)
• Benign Prostatic Hyperplasia (BPH) is a type of benign prostate hyperplasia (BPH)
• Both Erectile Dysfunction and Benign Prostatic Hyperplasia have indications and symptoms.

 

Pharmacology

Tadalafil is a specific inhibitor of phosphodiesterase type 5 (PDE5). PDE5 inhibition raises cGMP levels in smooth muscle cells. Smooth muscle relaxation and increased blood flow into the corpus cavernosum are both caused by cGMP, resulting in penile erection. PDE5 is also found in the prostate and bladder wall smooth muscles. PDE5 inhibition raises cGMP levels, causing smooth muscle relaxation in the prostate and bladder. Smooth muscle relaxation may enhance blood flow to the urinary system and widen the bladder neck opening, resulting in better voiding.

 

Dosage & Administration

Erectile Dysfunction: For most patients the recommended starting dose is 10 mg. The dose may be increased to 20 mg or decreased to 5 mg based on requirement. The maximum dosing frequency is once daily. Tadalafil is effective for up to 36 hours.

Benign prostatic hyperplasia: The recommended dose is 5 mg taken at the same time every day.

Combined Erectile Dysfunction and Benign prostatic hyperplasia: The recommended dose is 5 mg at the same time every day.

 

Interaction

Isosorbide, Nitroglycerin, Alpha adrenergic blockers, Antihypertensives, Alcohol, Antacids (magnesium hydroxide/aluminum hydroxide), Ketoconazole, Ritonavir, Erythromycin, Itraconazole, Grapefruit juice, other HIV protease inhibitors, Rifampin, Carbamazepine, Phenytoin, and Phenobarbital are examples

 

Contraindications

Nitrates (for example, Nitroglycerine, Isosorbide) may augment the hypotensive effects of Nitrates. Tadalafil hypersensitivity reactions

 

Side Effects

The most commonly reported adverse reactions are headache, dizziness, flushing and dyspepsia, nasal congestion, back pain, myalgia, swelling of eyelids is uncommon adverse reactions. The adverse events reported with Tadalafil were transient, and generally mild or moderate.

 

Pregnancy & Lactation

Tadalafil is not indicated for use by women. There are no studies of Tadalafil in pregnant women.

 

Precautions & Warnings

• Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.
• Tadalafil has vasodilator properties, resulting in mild and transient decreases in blood pressure
• There is limited clinical data on the safety of Tadalafil in the following groups; if prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician:
• Patients with severe renal insufficiency
• Patients with severe hepatic insufficiency
• Tadalafil should not be administered to patients with hereditary problems of galactose intolerance.
• The safety and efficacy of combinations of Tadalafil and other treatments for erectile dysfunction have not been studied. Therefore, the use of such combinations is not recommended.
• Caution should be exercised when Tadalafil is administered to patients with anatomical deformation of the penis.
• Patients who suffer from problems that increase the possibility of Priapism (sickle-cell anemia, multiple myeloma, leukemia) should use this product with caution.

 

Therapeutic Class

Erectile Dysfunction Drugs

 

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

 

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.