Facid HC 10g

Generic

Indications

Fusidic acid and hydrocodisone is indicated for the treatment of mild to moderately severe atopic dermalitis where Staph aureus is suspected as a contributing factor.

Pharmacology

Fusidic Acid BP 2 percent & Hydrocortisone Acetate BP 1 percent combo cream combines Fusidic Acid's powerful topical antibacterial action with Hydrocortisone Acetate's anti-inflammatory and anti-pruritic properties. Fusidic Acid is efficient against Staphylococci, Streptococci, Corynebacteria, Neisseria, and some Clostridia and Bacteroides when applied topically. Fusidic acid is an antibiotic that inhibits the synthesis of proteins in microorganisms. By stabilizing the ribosome-guanosine diphosphate elongation factor G-complex, it disrupts the translocation stage. This prevents aminoacyl t-RNA from binding to the ribosome and, as a result, prevents more amino acids from being transferred to the developing polypeptide. Hydrocortisone is the most common naturally occurring glucocorticosteroid in humans. Its major activity in pharmaceutical dosage is to diminish the skin's sensitivity to damage (i.e. anti-in ammatory). It also possesses anti-mitotic and immunosuppressive properties.

Dosage & Administration

Adults: This Cream should be applied 3 times daily and gently massaged onto the affected areas for 2 weeks. A shorter course should be considered if symptoms improve.

Children: It is not recommended in children under 3 years of age.

Interaction

Fusidic acid and hydrocodisone is indicated for the treatment of mild to moderately severe atopic dermalitis where Staph aureus is suspected as a contributing factor.

Contraindications

Facid HC@ is contraindicated in palients with hypersensitivlty to frrsidlc acid hydrocortisone acetate or olher components of the cream As wlth other topical antibiollc or corticosteroid combinalion preparations, Facid HC@ is contralnd cated in bacterial intections due 10 non-susceptible organisms' fungaL intectlons' tuberculosis of the skin, syphi itic skin infections, chicken pox' eruptions lol ow ng vaccinations and viral diseases of the skin in general.

Side Effect

Fusidic Acid has been known to cause moderate irritation at the application site, however this has seldom resulted in therapy being stopped. Hypersensitivity responses have been reported seldom. Dryness, itching, burning, local irritation, striae, skin atrophy, atrophy of subcutaneous tissues, telangiectasia, hypertrichosis, and changes in pigmentation are examples of adverse effects.

Pregnancy & Lactation

It is unknown whether Fusidic Acid and/or topical Hydrocortisone Acetate are safe to use during pregnancy or lactation. The possible benefits of using this cream during pregnancy or lactation must be evaluated against the dangers to the fetus or nursing infant.

Precautions & Warnings

Fusidic Acid and Hydrocortisone Acetate should not be used in or near the eye because Fusidic Acid can induce conjunctival irritation. Insufficient absorption may occur when administered beneath occlusive dressings, across large areas, or on the face, scalp, axillae, and scrotum, resulting in adrenal suppression and other systemic consequences.

Therapeutic Class

Hydrocortisone & Combined preparations

Storage Conditions

Store at a temperature below 30°C and away from light and moisture. Keep out of children's reach.

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.