Losectil 20

Generic

 

Indications

Omeprazole is shown for the treatment of- Gastric and duodenal ulcer NSAID-associated duodenal and gastric ulcer As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer Gastro-esophageal reflux disease Long-term administration of corrosive reflux disease Acid-related dyspepsia Severe ulcerating reflux esophagitis Prophylaxis of corrosive goal amid common anesthesia Zollinger-Ellison syndrome Helicobacter pylori-induced peptic ulcer.

 

Pharmacology

Omeprazole, a substituted benzimidazole, is an inhibitor of gastric acid secretion. It inhibits gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H⁺/K⁺ ATPase) enzyme system in the gastric parietal cell. After oral administration, the onset of the antisecretory effect occurs within one hour, with the maximum ef

 

Administration & Dosage

Oral-

• Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration; in severe or recurrent cases, dose to be increased to 40 mg daily; maintenance dose for recurrent duodenal ulcer, 20 mg once daily; in prevention of relapse in duodenal ulcer, 10-20 mg daily.
• NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks, continued for further 4 weeks, if not fully healed. 20 mg once daily is used as prophylaxis in patients with a history of NSAID-associated duodenal or gastric ulcers.
• Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks, if not fully healed; 40 mg once daily has been given for 8 weeks in gastro-esophageal reflux disease, refractory to other treatment; maintenance dose is 20 mg once daily.
• Long-term management of acid reflux disease: 10-20 mg daily.
• Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks.
• Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery.
• Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily (If daily dose is more than 80 mg, 2 divided dose should be used).
• Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents as detailed below: Amoxicillin 500 mg and Metronidazole 400 mg both three times a day for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice a day for one week, or Amoxicillin 1 g and Clarithromycin 500 mg both twice a day for one week.
• Paeditaric use in severe ulcerating reflux esophagitis (Child>1 year): If body-weight 10-20 kg, 10-20 -mg once daily for 4-12 weeks; if body-weight over 20 kg, 20-40 mg once daily for 4-12 weeks.IV Injection-
  
  • Prophylaxis of acid aspiration: Omeprazole 40 mg to be given slowly (over a period of 5 minutes) as an intravenous injection, one hour before surgery.
  • Duodenal ulcer, gastric ulcer or reflux oesophagitis: In patients with duodenal ulcer, gastric ulcer or reflux oesophagitis where oral medication is inappropriate, Omeprazole IV 40 mg once daily is recommended.
  • Zollinger- Ellison syndrome (ZES): In patients with Zollinger-Ellison Syndrome the recommended initial dose of Omeprazole given intravenously is 60 mg daily. Higher daily doses may be required and the dose should be adjusted individually. When doses exceed 60 mg daily, the dose should be divided & given twice daily.

 

Interaction

Diazepam, warfarin, and phenytoin can all be delayed by omeprazole. When Omeprazole is added to the treatment, it may be necessary to reduce the dose of warfarin or phenytoin. Omeprazole does not appear to interact with theophylline, propranolol, or antacids.

 

Contraindications

Omeprazole is not recommended for patients who have a known hypersensitivity to any of the formulation's ingredients.

 

Side Effect

Omeprazole is a medication that is generally well tolerated. Nausea, abdominal colic, paresthesia, dizziness, and headache have all been reported to be mild and transient, requiring no dosage adjustments.

 

Pregnancy & Lactation

US FDA pregnancy category of Omeprazole is C. In any case, comes about from three imminent epidemiological ponders demonstrate no unfavorable impacts of Omeprazole on pregnancy or on the wellbeing of the fetus/newborn child. There's no data accessible on the entry of Omeprazole into breast drain or its impacts on the neonate. Breast-feeding ought to, in this manner, be ceased, in case the utilize of Omeprazole is considered fundamental.

 

Precautions & Warnings

When a gastric ulcer is suspected, the possibility of a gastric cancer should be ruled out first, as treatment with Omeprazole may mask the symptoms and delay diagnosis.

 

Therapeutic Class

Inhibitor of the proton pump

 

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

 

Pharmaceutical Name