Prolok 20

Generic

Omeprazole

 

Indications

Omeprazole is shown for the treatment of- 

• Gastric and duodenal ulcer 
• NSAID-associated duodenal and gastric ulcer 
• As prophylaxis in patients with a history of 
• NSAID-associated duodenal and gastric ulcer 
• Gastro-esophageal reflux disease 
• Long-term administration of corrosive reflux disease 
• Acid-related dyspepsia 
• Severe ulcerating reflux esophagitis 
• Prophylaxis of corrosive desire amid common anesthesia Zollinger-Ellison syndrome 
• Helicobacter pylori-induced peptic ulcer.

Dosage and Administration

Oral-

• Benign gastric and duodenal ulcer: 20 mg once day by day for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration; in extreme or repetitive cases, measurements to be expanded to 40 mg every day; upkeep dosage for repetitive duodenal ulcer, 20 mg once day by day; in avoidance of backslide in duodenal ulcer, 10-20 mg daily.
• NSAID-associated duodenal or gastric ulcer: 20 mg once every day for 4 weeks, proceeded for encourage 4 weeks, in the event that not completely recuperated. 20 mg once every day is utilized as prophylaxis in patients with a history of NSAID-associated duodenal or gastric ulcers. 
• Gastro-esophageal reflux malady: 20 mg once every day for 4 weeks, proceeded for advance 4-8 weeks, on the off chance that not completely recuperated; 40 mg once day by day has been given for 8 weeks in gastro-esophageal reflux infection, hard-headed to other treatment; upkeep dosage is 20 mg once daily. 
• Long-term administration of corrosive reflux malady: 10-20 mg daily.
• Acid-related dyspepsia: 10-20 mg once every day for 2-4 weeks.
• Prophylaxis of corrosive yearning: 40 mg on the going before evening, at that point 40 mg 2-6 hours some time recently surgery. 
• Zollinger-Ellison disorder: At first 60 mg once every day; normal extend 20-120 mg day by day (In the event that every day dosage is more than 80 mg, 2 partitioned measurements ought to be used).
• Helicobacter pylori destruction regimen in peptic ulcer illness: Omeprazole is suggested at a measurements of 20 mg twice every day in affiliation with antimicrobial specialists as nitty gritty underneath: Amoxicillin 500 mg and Metronidazole 400 mg both three times a day for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice a day for one week, or Amoxicillin 1 g and Clarithromycin 500 mg both twice a day for one week.
• Paeditaric utilize in extreme ulcerating reflux esophagitis (Child>1 year): On the off chance that body-weight 10-20 kg, 10-20 -mg once day by day for 4-12 weeks; in the event that body-weight over 20 kg, 20-40 mg once day by day for 4-12 weeks.

IV Injection- 

• Prophylaxis of corrosive goal: Omeprazole 40 mg to be given gradually (over a period of 5 minutes) as an intravenous infusion, one hour some time recently surgery. 
• Duodenal ulcer, gastric ulcer or reflux oesophagitis: In patients with duodenal ulcer, gastric ulcer or reflux oesophagitis where verbal pharmaceutical is unseemly, Omeprazole IV 40 mg once day by day is recommended. 
• Zollinger- Ellison disorder (ZES): In patients with Zollinger-Ellison Disorder the prescribed introductory dosage of Omeprazole given intravenously is 60 mg day by day. Higher every day dosages may be required and the measurements ought to be balanced exclusively. When measurements surpass 60 mg day by day, the measurements ought to be isolated & given twice every day.

 

Interaction

Omeprazole can drag out the disposal of diazepam, warfarin and phenytoin. So, diminishment of warfarin or phenytoin measurements may be essential when Omeprazole is included to the treatment. There's no prove of an interaction of Omeprazole with theophylline, propranolol or stomach settling agents.

 

Contraindications

Patients known to have hypersensitivity to any component of the preparation.

 

Side Effects

Omeprazole is well endured and unfavorable responses have by and large been gentle and reversible. Gastrointestinal side impacts incorporate the runs, obstruction, stomach torment, nausea/vomiting and tooting. Central and fringe anxious framework clutters detailed incorporate cerebral pain, tipsiness, paraesthesia, drowsiness, a sleeping disorder and vertigo.

Others incorporate extreme touchiness responses, e.g angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic stun. Expanded sweating, fringe edema, obscured vision, taste unsettling influence andhyponatremia.

 

Pregnancy & Lactation

US FDA pregnancy category of Omeprazole is C. Be that because it may, comes about from three planned epidemiological ponders show no antagonistic impacts of Omeprazole on pregnancy or on the wellbeing of the fetus/newborn child. There's no data accessible on the entry of Omeprazole into breast drain or its impacts on the neonate. Breast-feeding ought to, subsequently, be suspended, on the off chance that the utilize of Omeprazole is considered basic.

 

Precautions & Warnings

Omeprazole should be given in reduced dosage to patients with impaired hepatic function.

Use in pregnancy: Results from three prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child. Omeprazole can be used during pregnancy.

Use in lactation: Omeprazole is excretedin breast milk but is not likely to influence the child when the rapeuticdoses are used. Like other drugs it should only be used during nursing if considered essential.

 

Therapeutic Class

Proton Pump Inhibitor

 

Storage Conditions

Keep underneath 30°C temperature, absent from light & dampness. Keep out of the reach of children.

 

Pharmaceutical Name

Ibn Sina Pharmaceuticals Ltd.