Mecolagin 0.5

Generic

Mecobalamin

 

Indications

• Peripheral Neuropathies
• Diabetic Neuropathy
• Verteberal Syndrome
• Nerve Compression Syndrome
• Multiple sclerosis
• Amyotrophic lateral sclerosis
• Parkinson’s disease
• Alzheimer’s disease
• Diabetic retinopathy
• Entrapment neuropathy
• Drug induced neuropathy
• Megaloblastic anemia due to Vitamin B12 deficiency

 

Pharmacology

Mecobalamin is the neurologically active form of vitamin B12, which is found in the body as a water-soluble vitamin. It's a cofactor in the enzyme methionine synthase, which helps methionine regenerate from homocysteine by transferring methyl groups. It boosts erythrocyte production in anemia by boosting nucleic acid synthesis in the bone marrow as well as erythrocyte maturation and division.

 

Dosage & Administration

Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.

Injection:

Peripheral neuropathies: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.

Megaloblastic anemia: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy.

 

Interaction

Neomycin, aminosalicylic acid, H2-blockers, and colchicine all reduced GI tract absorption. Oral contraceptives lower serum concentrations. Parenteral chloramphenicol has less of an effect on anemia.

 

Contraindications

Hypersensitivity to any of the product's ingredients.

 

Side Effects

Mecobalamin is generally well tolerated. However, following the delivery of Mecobalamin, some adverse effects such as GI discomfort (including anorexia, nausea, or diarrhea) and rash may occur.

 

Pregnancy & Lactation

It is not advised to use during pregnancy or nursing.

 

Precautions & Warnings

If there is no response to the treatment after a particular period of time, it should not be used for months.

 

Therapeutic Class

Drugs for Megaloblastic Anemia.

 

Storage Conditions

Store at room temperature if used orally. Moisture and light should be avoided.

Store at room temperature if using as a parenteral. Direct sunlight should be avoided.

 

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.