Nerviton 0.5

Generic

Mecobalamin

 

Indications

The use of mecobalamin is recommended in the following conditions:

• Peripheral Neuropathies
• Diabetic Neuropathy is a type of neuropathy caused by diabetes.
• Verteberal Syndrome is a condition that affects animals.
• Nerve Compression Syndrome is a condition when the nerves are compressed.
• Multiple sclerosis (MS) is a disease that affects people
• Amyotrophic lateral sclerosis (ALS) is a type of amyotrophic lateral
• Parkinson's disease is a neurological disorder that affects people.
• Alzheimer's disease is an illness that affects people of all
• Diabetic retinopathy is a kind of retinopathy caused by diabetes.
• Neuropathy caused by entrapment

 

Pharmacology

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

 

Dosage & Administration

Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms. 

Injection:

• Peripheral neuropathies: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms. 
• Megaloblastic anemia: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy

 

Interaction

Neomycin, aminosalicylic acid, H2-blockers, and colchicine all reduced GI tract absorption. Oral contraceptives lower serum concentrations. Parenteral chloramphenicol has less of an effect on anemia.

 

Contraindications

Hypersensitivity to any component of this product.

 

Side Effects

Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.

 

Pregnancy & Lactation

Not recommended during pregnancy & lactation.

 

Precautions & Warnings

The medicine should not be used for months if there is no response at all after its use for a certain period of time. Use in Special Populations Use in children: Not recommended.

 

Therapeutic Class

Drugs for Megaloblastic Anemia

 

Storage Conditions

Oral: Store at room temperature. Protect from moisture and light. Parenteral: Store at room temperature. Do not expose to direct light.

 

Pharmaceutical Name

Opsonin Pharma Ltd.