Napexa 500/20

Generic

Indications

Naproxen and Esomeprazole are used to treat the signs and symptoms of osteoarthritis.

• Rheumatoid arthritis is a type of arthritis that affects the joints.
• Ankylosing spondylitis and to reduce the risk of gastric ulcers in patients who are at risk of NSAID-related gastric ulcers

Pharmacology

This comprises of an quick discharge Esomeprazole Magnesium layer & an enteric-coated Naproxen center. As a result, Esomeprazole is discharged to begin with into the stomach, earlier to the disintegration of Naproxen within the small intestine. Naproxen could be a NSAID with pain relieving & antipyretic properties. The instrument of action of Naproxen is to restrain the prostaglandin amalgamation. Esomeprazole could be a proton pump inhibitor that smothers gastric corrosive discharge by particular hindrance of the H+/k+ -ATPase within the gastric parietal cell by acting particularly on the proton pump, Esomeprazole squares the ultimate step in corrosive generation, in this way lessening gastric causticity.

Administration & Dosage

Carefully consider the potential benefits & risks of this tablet & other treatment options before deciding to use this tablet. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. If a dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.

Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis-

• Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole

Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older-

• Weight greater than 50 kg: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
• Weight 38 kg to less than 50 kg: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.

Interaction

Hypersensitivity to any of the tablet's ingredients or substituted benzimidazoles.
After taking aspirin or other NSAIDs, you may experience asthmay urticaria or other allergic reactions.
In the case of coronary artery bypass graft (CABG) surgery, use during the peri-operative period.

Contraindications

NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers when taken together.
When this tablet is taken with warfarin, the risk of a bleeding complication is increased.
Esomeprazole inhibits gastric acid secretion and may interfere with the absorption of drugs whose bioavailability is influenced by gastric pH.

Side Effect

This medication is generally well tolerated. Erosive gastritis, dyspepsia, gastritis, diarrhea, gastric ulcer, upper abdominal pain, nausea, and other adverse reactions were the most common in clinical trials (>5%).

Pregnancy & Lactation

Category C pregnancy. It should be avoided in late pregnancy because it may cause premature closure of the ductus arteriosus. Because of the Naproxen component, this tablet should not be used by nursing mothers.

Precautions & Warnings

Patients with a history of cardiovascular disease or risk factors may be at higher risk. In patients with fluid retention or heart failure, this tablet should be used with caution.

Therapeutic Class

Non-steroidal anti-inflammatory drugs, drugs for osteoarthritis, drugs for rheumatoid arthritis (NSAIDs)

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

Pharmaceutical Name