Osartil 50

Indications

Hypertension: Osartil 50 is used to treat high blood pressure. It can be taken alone or with other antihypertensive medications (eg. thiazide diuretics).

Losartan Potassium is approved to prevent the course of renal disease in hypertensive type-2 diabetics with proteinuria, defined as a urine albumin to creatinine ratio of more than 300 mg/g.

 

Pharmacology

Losartan Potassium is the first angiotensin II receptor blocker that is not a peptide. It binds to the AT1 receptor, which can be present in a variety of tissues (including vascular smooth muscle, the adrenal gland, the kidneys, and the heart), and inhibits a number of biological processes, including vasoconstriction and the release of the hormone aldosterone, which causes hypertension.

 

Dosage & Administration

The usual starting and maintenance dose is 50 mg once daily for most patients. If the antihypertensive effect of using 50 mg once daily is inadequate, 25 mg twice daily is recommended prior to increasing the dose. For patients with intravascular volume depletion (e.g., those treated with high-dose diuretics), a starting dose of 25 mg once daily should be considered. Losartan Potassium can be administered once or twice daily. The total daily dose ranges from 25 mg to 100 mg.

 

Interaction

Osartil 50 active metabolite levels are reduced by rifampicin and fluconazole. When Losartan Potassium and hydrochlorothiazide are taken together, the antihypertensive effects may be amplified. Serum potassium levels may rise if potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or potassium-containing salt replacements are used at the same time. Losartan's antihypertensive impact may be reduced by indomethacin, a nonsteroidal anti-inflammatory medicine. When an ACE inhibitor, angiotensin receptor antagonist, an anti-inflammatory medication, and a thiazide diuretic are used at the same time, the risk of renal impairment is increased.

 

Contraindications

Osartil 50 is not recommended for pregnant women or those who are hypersensitive to any of the product's ingredients. In diabetic patients, Losartan Potassium should not be used with Aliskiren.

 

Side Effects

The negative effects of Osartil 50 are minor and only last a short time. Dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection are the most prevalent adverse effects. Fatigue, edema, stomach pain, chest pain, nausea, headache, and pharyngitis are some of the other side effects.

 

Pregnancy & Lactation

D is the pregnancy category. If Osartil 50 is given during the second or third trimesters of pregnancy, the risk to the fetus increases. Losartan Potassium is not known whether it is excreted in human milk, but because many drugs are, and because of the potential for adverse effects on the nursing infant, a decision should be made whether to stop nursing or stop taking the drug, taking into account the drug's importance to the mother.

 

Precautions & Warnings

Osartil 50 use throughout the second and third trimesters of pregnancy lowers fetal renal function and increases fetal and neonatal morbidity and mortality. Symptomatic hypotension can develop in people who have lost intravascular volume (e.g., those on high-dose diuretics). In cirrhotic patients, the plasma concentration of Losartan Potassium is much higher. Renal impairment has been linked to changes in renal function, including renal failure.

 

Therapeutic Class

Angiotensin-ll receptor blocker

 

Storage Conditions

Keep away from light and heat in a dry location. Keep out of children's reach.

 

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.

 

Generic

Losartan Potassium

 

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