Quiet 25

Indications

Quiet 25 is used to treat acute and chronic psychoses, such as schizophrenia, as well as bipolar disorder, including treatment of manic episodes that meet DSM-IV criteria for mania in bipolar disorder, treatment of depressive episodes in bipolar disorder, and maintenance treatment of bipolar I disorder in combination with a mood stabilizer to prevent relapse.

 

Pharmacology

The instrument of activity of Quetiapine, as with other drugs having viability within the treatment of schizophrenia and intense hyper scenes related to bipolar clutter, is obscure. Be that as it may, it has been proposed that this drug's viability in schizophrenia intercedes through a combination of dopamine sort 2 (D2 ) and serotonin sort 2 (5HT2) hostility. Enmity at receptors other than dopamine and 5HT 2 with comparable receptor affinities may clarify a few of the other impacts of Quetiapine. Quetiapine's hostility of histamine H1 receptors may clarify the lethargy watched with this sedate. Quetiapine's hostility of adrenergic α1 receptors may clarify the orthostatic hypotension watched with this drug.

 

Dosage & Administration

Acute and chronic psychoses, including schizophrenia: Quetiapine should be administered twice daily, with or without food. The total daily dose for the first four days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4). From Day 4 onwards, the dose should be titrated to the usual effective dose range of 300-450 mg/day. However, this may be adjusted, depending on the clinical response and tolerability of the individual patient, within the range 150 to 750 mg/day.

Manic episodes associated with bipolar disorder: Quetiapine should be administered twice daily, with or without food. The total daily dose for the first four days of therapy is 100 mg (Day 1), 200 mg (Day 2), 300 mg (Day 3) and 400 mg (Day 4). Further dosage adjustments up to 800mg/day by Day 6 should be in increments of no greater than 200 mg/day. The dose may be adjusted depending on clinical response & tolerability of the individual patient, within the range of 200 to 800 mg/day. The usual effective dose is in the range of 400 to 800mg/day.

Depressive episodes associated with bipolar disorder: Quetiapine should be administered once daily at bedtime, with or without food. The usual dose is 300 mg/day. The daily dose for the first four days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4). Quetiapine can be titrated to 400 mg on Day 5 and up to 600mg by Day 8. Antidepressant efficacy was demonstrated with Quetiapine at 300mg and 600 mg, however no additional benefit was seen in the 600mg group during short term treatment.

Maintenance treatment of bipolar I disorder in combination with mood stabilizers: Patients who have responded to Quetiapine in combination therapy with a mood stabiliser for acute treatment of bipolar disorder should continue on Quetiapine therapy at the same dose. Quetiapine dose can be re-adjusted depending on clinical response and tolerability of the individual patient. Efficacy was demonstrated with Quetiapine (administered twice daily totalling 400mg to 800mg a day) as combination therapy with a mood stabilizer.

 

Interaction

When Quetiapine is taken with other medications that are known to cause electrolyte imbalance or increase the QT interval, caution should be exercised. When Quetiapine was taken with thioridazine or carbamazepine, the clearance of Quetiapine increased. Quetiapine clearance was also increased when it was given in combination with another microsomal enzyme inducer, phenytoin.

 

Contraindications

Quiet 25 is contraindicated in patients who are easily affected by it.

 

Side Effects

Somnolence, dizziness, dry mouth, withdrawal (discontinuation) symptoms, elevations in serum triglyceride levels, elevations in total cholesterol (predominantly LDL cholesterol), decreases in HDL cholesterol, weight gain, decreased hemoglobin, and extrapyramidal symptoms are the most commonly reported Adverse Drug Reactions (ADRs) with Quetiapine.

 

Pregnancy & Lactation

The security and adequacy of Quetiapine amid human pregnancy have not been built up. Subsequently, Quetiapine ought to as it was being utilized amid pregnancy on the off chance that the benefits legitimize the potential dangers and the managed measurements and term of treatment ought to be as moo and as brief as conceivable. The degree to which Quetiapine is excreted into the human drain is obscure. Ladies who are breastfeeding ought to in this manner be exhorted to maintain a strategic distance from breastfeeding whereas taking Quetiapine.

 

Precautions & Warnings

The security and viability of Quetiapine amid human pregnancy have not been set up. In this manner, Quetiapine ought to as it was being utilized amid pregnancy on the off chance that the benefits legitimize the potential dangers and the managed dosage and length of treatment ought to be as moo and as brief as conceivable. The degree to which Quetiapine is excreted into the human drain is obscure. Ladies who are breastfeeding ought to in this manner be exhorted to maintain a strategic distance from breastfeeding whereas taking Quetiapine.

 

Therapeutic Class

Atypical neuroleptic drugs.

 

Storage Conditions

Keep away from light and moisture in a cool, dry location (below 30° C). Keep out of children's reach.

 

Pharmaceutical Name

Incepta Pharmaceuticals Ltd

 

Generic

Quetiapine Fumarate

 

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