Rifagut 200

Generic

Rifaximin.

 

Indications

Rifaximin is indicated in-

• Treatment of traveler's diarrhea by noninvasive strains of E. coli
• reduction in risk of overt hepatic encephalopathy
• bacterial overgrowth of irritable bowel syndrome.

 

Pharmacology

Rifaximin could be a semisynthetic, rifamycin-based non-systemic anti-microbial. Exceptionally small of the senate will pass the gastrointestinal divider into the circulation as is common for other sorts of orally managed anti-microbials. Rifaximin represses bacterial RNA amalgamation by its activity on the beta-subunit of the DNA-dependent RNA polymerase. It appears the same wide range of action as rifamycin which applies bactericidal activity against numerous species of Gram-positive and Gram-negative, oxygen-consuming, and anaerobic microbes.

 

Dosage & Administration

Traveler's Diarrhea: For patients ≥12 years of age: 200 mg 3 times daily for 3 days.
Hepatic Encephalopathy: For patients ≥18 years of age: 550 mg 2 times daily.
Bacterial overgrowth of irritable bowel syndrome: 400 mg 3 times daily for 10 days or 550 mg 3 times daily for 14 days. Can be taken with or without food

 

Interaction

In an in vitro ponder has recommended that Rifaximin actuates CYP3A4. Be that as it may, in patients with ordinary liver work, Rifaximin at the prescribed dosing regimen isn't anticipated to actuate CYP3A4.

 

Contraindications

Contraindicated in patients with an extreme touchiness to Rifaximin or to any of the rifamycin antimicrobial specialists, or any components of this item.

 

Side Effects

Flatulence, headache, abdominal pain, rectal tenesmus, defecation urgency, nausea, constipation, pyrexia, and vomiting are some of the side effects. Anaphylaxis, angioneurotic edema, and exfoliative dermatitis have all been recorded as side effects.

 

Pregnancy & Lactation

Pregnancy category C. It is not known whether Rifaximin is excreted in human milk or not.

 

Precautions & Warnings

Rifaximin isn't found to be compelling in patients with loose bowels complicated by fever and/or blood within the stools. Rifaximin treatment ought to be suspended in the event that the run's side effects get more awful or endure for more than 24-48 hours and elective anti-microbial treatment ought to be considered. Pseudomembranous colitis has been detailed with about all antibacterial operators and may extend in seriousness from mellow to life-threatening. Hence, it is vital to consider this determination in patients who show with the run’s consequent to the organization of antibacterial specialists.

 

Therapeutic Class

4-Quinolone preparations.

 

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name

Opsonin Pharma Ltd.