Rosu 10

Generic

Rosuvastatin

 

Indications

Heterozygous Hypercholesterolemia is treated with rosuvastatin (Familial and Non familial)

Hypercholesterolemia Homozygous (Familial)

Dyslipidemia (Mixed) (Fredrickson Type IIa and IIb)

Primary cardiovascular disease prevention.

 

Pharmacology

HMG-CoA reductase is the rate-limiting enzyme that transforms 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. Rosuvastatin has two mechanisms for altering lipid levels. To begin, it boosts the amount of hepatic LDL receptors on the cell surface, which improves LDL absorption and degradation. Second, Rosuvastatin reduces the total number of VLDL and LDL particles by inhibiting VLDL synthesis in the liver.

 

Dosage & Administration

Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

HoFH: Starting dose 20 mg/day.

Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.

 

Interaction

The following are notable Rosuvastatin medication interactions: Cyclosporine: When used together, Rosuvastatin exposure is increased. The daily dose of rosuvastatin should be kept to 5 mg.

Combination should be avoided with gemfibrosil. If taken concurrently, the dose of rosuvastatin should be kept at 10 mg once a day.

The combination of lopinavir/ritonavir or atazanavir/ritonavir increases Rosuvastatin exposure. The dose of rosuvastatin should be reduced to 10 mg once daily.

Combination of coumarin anticoagulants increases the international normalized ratio (INR). Prior to commencing Rosuvastatin, make sure your INR is stable. When starting or stopping Rosuvastatin medication, the INR should be checked often until it is stable.

Concurrent lipid-lowering therapies: Using fibrates and niacin products at the same time may raise the risk of skeletal muscle side effects.

 

Contraindications

If you have a known hypersensitivity to any of the product's ingredients, you should avoid taking rosuvastatin.

Unexplained chronic rises in hepatic transaminase values are a sign of liver illness.

Women who are pregnant or may become pregnant

Mothers who are breastfeeding.

 

Side Effects

Rosuvastatin is well tolerated by most people. Headache, myalgia, constipation, asthenia, stomach pain, and nausea were the most common side effects linked to Rosuvastatin.

 

Pregnancy & Lactation

The safety of the drug in pregnant women has yet to be determined. Rosuvastatin is not known whether or whether it is excreted in human milk.

 

Precautions & Warnings

Effects on skeletal muscle (e.g., myopathy and rhabdomyolysis): Usage of the 40 mg dose, advanced age (>65 years), hypothyroidism, renal impairment, and use of cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir, or certain other lipid-lowering medicines all enhance the risks. Patients should be encouraged to report any unexplained muscle discomfort, soreness, or weakness as soon as possible. If indications or symptoms arise, rosuvastatin can be stopped.

Abnormalities in liver enzymes and monitoring: Hepatic transaminases might be persistently elevated.

Before and during treatment, liver enzymes should be checked.

 

Therapeutic Class

Statins and other anti-anginal and anti-ischaemic medications.

 

Storage Conditions

Keep the temperature below 30°C and keep it away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name

Popular Pharmaceuticals Ltd.