Sitap 50

Generic

Sitagliptin

 

Indications

Sitagliptin is used as a supplement to diet and exercise to enhance glycemic control in persons with type 2 diabetes.

Important Use Restrictions: Sitagliptin should not be used in type 1 diabetes patients or for the treatment of diabetic ketoacidosis because it is ineffective in these situations. Patients with a history of pancreatitis have not been investigated with sitagliptin. It's unclear whether people who have had pancreatitis in the past are more likely to develop pancreatitis when using Sitagliptin.

 

Pharmacology

Sitagliptin is a DPP-4 inhibitor that is thought to work in type 2 diabetes patients by decreasing the inactivation of incretin hormones. Sitagliptin increases the concentrations of active intact hormones, which increases and prolongs the effect of these hormones. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GDIP) are two incretin hormones.

 

Dosage & Administration 

The recommended dose of sitagliptin is 50 mg twice a day and 100 mg once daily. Sitagliptin can be taken with or without food.

 

Interaction

Effects of sitagliptin on other Drugs: Sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptive.

Digoxin: Sitagliptin slightly increases the mean of Digoxin concentration. However, no dose adjustment of either drug is required.

 

Contraindications                                                                 

History of a serious hypersensitivity reaction to sitagliptin, such as anaphylaxis or angioedema.

 

Side Effects

The most common adverse reactions include headache, upper respiratory tract infection and nasopharyngitis. Hypoglycemia may occur in patients treated with the combination to Sitagliptin and sulfonylurea and add on to insulin.

 

Pregnancy & Lactation

Pregnancy Classification B. Rats and rabbits have been used in reproduction research. Because animal reproduction studies do not always predict human response, this medication should only be used during pregnancy if absolutely necessary. Sitagliptin is secreted in a 4:1 milk-to-plasma ratio in nursing rats' milk. Sitagliptin is not known to be excreted in human milk. Because many medications are excreted in human milk, when sitagliptin is given to a breastfeeding woman, caution should be maintained.

                                                                                                                   

Precautions & Warnings

Sitagliptin is a DPP-4 inhibitor that is thought to work in type 2 diabetes patients by decreasing the inactivation of incretin hormones. Sitagliptin increases the concentrations of active intact hormones, which increases and prolongs the effect of these hormones. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GDIP) are two incretin hormones.

 

Therapeutic Class

Dipeptidyl Peptidase-4 (DPP-4) inhibitor

 

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name

ACI Limited