TCL-R 20

Indications of TCL-R 20

TCL-R 20 is shown as an aide to count calories to diminish hoisted add up to cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides levels in taking after infections when the reaction to slim down and other non-pharmacological measures is insufficient.

• To reduce total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolemia.
• To reduce elevated cholesterol and triglycerides inpatient with mixed dyslipidemia (Fredrickson Type IA and Ib).
• For the treatment of patients with elevated serum triglyceride levels in hypertriglyceridemia (Fredrickson Type IV).
• For the treatment of patients with dysbetalipoproteinemia (Fredrickson Type III).
• To reduce cardiac ischemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease with elevated LDL-cholesterol levels.
• To reduce total and LDL-cholesterol concentrations in patients with hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation.

 

Pharmacology of TCL-R 20

Atorvastatin could be a specific inhibitor of HMG-CoA reductase. This chemical is the rate-limiting protein mindful for the change of HMG-CoA to mevalonate, a forerunner of sterols, counting cholesterol. Atorvastatin brings down plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol amalgamation within the liver and increments the number of hepatic LDL receptors on the cell surface for upgraded take-up and catabolism of LDL.

 

Dosage & Administration

Primary hypercholesterolemia and combined hyperlipidemia-

• Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to the max. 80 mg once daily.
• Child (10-18 years): Initially 10 mg once daily, increased, if necessary, at intervals of at least 4 weeks to the usual max. 20 mg once daily.

Familial hypercholesterolemia-

• Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolemia).
• Child (10-18 years): Initially 10 mg once daily, increased, if necessary, at intervals of at least 4 weeks to the usual max. 80 mg once daily.

Prevention of cardiovascular events-

• Adults: Initially 10 mg once daily adjusted according to the response.

 

Interaction of TCL-R 20

The chance of myopathy amid treatment with TCL-R 20 is expanded with the concurrent organization of cyclosporin, fabric corrosive subsidiaries, erythromycin, azole antifungals, and niacin. No clinically critical intuition was seen when TCL-R 20 was managed with antihypertensives or hypoglycemic operators. Patients ought to be closely checked in the event that Atorvastatin is included in digoxin, erythromycin, verbal contraceptives, colestipol, stomach settling agent, and warfarin.

 

Contraindications

TCL-R 20 ought to not be utilized in understanding with extreme touchiness to any component of this medicine. Atorvastatin is contraindicated in dynamic liver illness or unexplained determining heights of serum transaminases. It is additionally contraindicated in understanding with history of genuine antagonistic response to earlier organization of HMG-CoA reductase inhibitors.

 

Side Effect of TCL-R 20

TCL-R 20 is well tolerated by most people. Constipation, flatulence, dyspepsia, and abdominal pain are the most common Atorvastatin side effects. Infection, headache, back pain, rash, asthenia, arthralgia, and myalgia are some of the other side effects.

 

Pregnancy & Lactation

Pregnancy: TCL-R 20 is contraindicated amid pregnancy. Security in pregnant ladies has not been built up. No controlled clinical trials with atorvastatin have been conducted in pregnant ladies. Uncommon reports of innate inconsistencies taken after the intrauterine presentation to HMG-CoA reductase inhibitors have been gotten. Creature ponders have appeared harmful to generations. Maternal treatment with atorvastatin may diminish the fetal levels of mevalonate which may be a forerunner of cholesterol biosynthesis. TCL-R 20 ought to not be used in ladies who are pregnant, attempting to end up pregnant, or suspect they are pregnant. Treatment with atorvastatin ought to be suspended for the term of pregnancy or until it has been decided that the lady isn't pregnant

Lactation: It isn't known whether TCL-R 20 or its metabolites are excreted in the human brain. In rats, plasma concentrations of atorvastatin and its dynamic metabolites are comparable to those in the drain.

 

Precautions & Warnings

Effects on the liver: Liver function tests should be done before starting treatment and then on a regular basis after that. In patients who drink a lot of alcohol or have a history of liver illness, TCL-R 20 should be administered with caution. If severely raised CPK levels or myopathy is diagnosed or suspected, atorvastatin medication should be stopped.

 

Therapeutic Class

Other Anti-anginal & Anti-ischemic drugs, Statins.

 

Storage Conditions

Protect from light and store in a cool, dry location. Keep out of children's reach.

 

Pharmaceutical Name of TCL-R 20

Aristopharma Ltd

 

Generic of TCL-R 20

Atorvastatin Calcium

 

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