Trumen 50

Generic

 

Indications

Tramadol is used for the treatment of moderate to severe painful conditions. These include:

• Postoperative pain
• Colic and spastic pain
• Cancer pain
• Joint pain
• Neck and back pain
• Pain associated with osteoporosis.

 

Pharmacology

Tramadol could be a centrally acting engineered pain relieving compound. It hinders the re take-up of neurotransmitters- serotonin and noradrenaline. Hence it alters the transmission of torment motivations by actuating both slipping serotonergic pathways and noradrenergic pathways included in absense of pain. The pain relieving impacts of Tramadol are interceded through incitement of mu-opioid receptors and backhanded balance of central monoaminergic inhibitory pathways.

 

Administration & Dosage

Capsule or Tablet: Usual doses are 50 to 100 mg every four to six hours. For acute pain an initial dose of 100 mg is required. For chronic painful conditions an initial dose of 50 mg is recommended. Subsequent doses should be 50 to 100 mg administered 4-6 hourly. The dose level and frequency of dosing will depend on the severity of the pain.The total daily dosage by mouth should not exceed 400 mg.

Sustained Release Capsule or Tablet: One SR capsule or tablet every 12 hours, for example first one in the morning and then at the same time in the evening. The number of capsules taken at a time will depend upon severity of pain, but it should not be taken more frequently than every 12 hours.The total daily dosage by mouth should not exceed 400 mg.Injection: A dose of 50-100 mg may be given every 4 to 6 hours by intramuscular or by intravenous infusion. For the treatment of postoperative pain,the initial dose is 100 mg followed by 50 mg every 10 to 20 minutes if necessary to a maximum of 250 mg in the first hour. Thereafter, doses are 50 to 100 mg every 4 to 6 hours up to a total daily dose of 600 mg.

Suppository: Tramadol suppository should be administered rectally. For adults usual dose is 100 mg Tramadol Hydrochloride 6 hourly. In general, 400 mg Tramadol Hydrochloride (4 Tramadol suppository) per day sufficient. However, for the treatment of Cancer pain and severe pain after operations much higher daily doses can be used.

 

Interaction

In common, doctor require not be concerned approximately drugs connection with Tramadol. The monoamine oxidase (MAO) inhibitors speak to the as it were sedate lesson not suggested for combination with Tramadol. Concomitant organization of carbamazepine with Tramadol causes a critical increment in Tramadol digestion system and it requires to extend the dosage of Tramadol.

 

Contraindications

Tramadol is contraindicated in persons having hypersensitivity to this drug. It is also contraindicated in acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs.

 

Side Effects

Commonly happening side-effects are dizziness/vertigo, sickness, stoppage, cerebral pain, drowsiness, spewing, pruritus, CNS incitement, asthenia, sweating, dyspepsia, dry mouth, the runs. Less commonly happening side-effects incorporate discomfort, unfavorably susceptible response, weight misfortune, vasodilatation, palpitations, stomach torment, anorexia, tooting, GI dying, hepatitis, stomatitis etc.

 

Pregnancy & Lactation

Safe use of Tramadol in pregnancy has not been established. Tramadol has been shown to cross the placenta. There are no adequate and well-controlled studies in pregnant women. Therefore, Tramadol should be used during pregnancy only if the potential benefit justifies the risk to the foetus. Tramadol Hydrochloride should not be administered during breast feeding as Tramadol and its metabolites have been detected in breast milk.

 

Precautions & Warnings

Respiratory discouragement: When expansive dosages of tramadol are managed with soporific with analgesic drugs or liquor, respiratory sadness may result. In this manner, tramadol ought to be managed cautiously in patients at hazard for respiratory depression. Opioid reliance: Tramadol isn't suggested for patients who are subordinate on opioids. Concomitant CNS depressants: Tramadol ought to be utilized with caution and in diminished doses when regulating to patients accepting CNS depressants such as liquor, opioids, anesthetic specialists, phenothiazines, tranquilizers or narcotic hypnotics. Concomitant MAO inhibitors: Tramadol ought to be utilized with awesome caution in patients taking MAO inhibitors, since tramadol hinders the take-up of norepinephrine and serotonin.

 

Therapeutic Class

Opioid analgesics

 

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

 

Pharmaceutical Name