Urosin 0.4

Generic

 

Indications

Tamsulosin Hydrochloride is a medication used to treat the symptoms of benign prostatic hyperplasia (BPH).

 

Pharmacology

Tamsulosin, a selective alpha1 adrenoceptor blocker, shows alpha1 A adrenoceptor selectivity in the human prostate. Blocking these adrenoceptors causes smooth muscle in the bladder neck and prostate to relax, resulting in increased urine flow and a decrease in BPH symptoms. Tamsulosin hydrochloride capsule 0.4mg absorbs almost completely (90 percent ).

 

Dosage & Administration

Tamsulosin Hydrochloride 0.4 mg (one capsule) daily, to be taken after meal at night. The dose may be increased after 2 to 4 weeks, if necessary, to Tamsulosin Hydrochloride 0.8 mg (two capsules) once daily. If Tamsulosin Hydrochloride administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, therapy should be started again with the Tamsulosin Hydrochloride 0.4 mg (one capsule) once daily dose. The capsule should be swallowed whole with a glass of water (about 150 ml) in the standing or sitting position. The capsule should not be crunched or chewed, as this will interfere with the modified release of the active ingredient.

 

Interaction

The use of other alfa1-adrenoceptor antagonists at the same time may cause hypotension. When Tamsulosin was combined with atenolol, enalapril, or nifedipine, no interactions were observed. Tamsulosin plasma levels rise with concomitant cimetidine and fall with concomitant frusemide, but because levels remain within the normal range, posology does not need to be changed.

 

Contraindications

Patients with hypersensitivity to tamsulosin hydrochloride, a history of orthostatic hypotension, or severe hepatic insufficiency should not take it.

 

Side Effects

Dizziness, abnormal ejaculation, and, less frequently, headache, asthenia, postural hypotension, and palpitations have all been reported as side effects of Tamsulosin use.

 

Pregnancy & Lactation

Tamsulosin should not be used during pregnancy or lactation.

 

Precautions & Warnings

During orthostatic provocation testing after the first dose, transient postural symptoms have occurred on rare occasions. It is not recommended for use in patients who have micturition syncope.

Effects on ability to drive and operate machines: There is no evidence that Tamsulosin impairs one's ability to drive or operate machines. Patients should be aware, however, that dizziness can be dangerous.

 

Therapeutic Class

Urinary incontinence/BPH/ Urinary retention

 

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

 

Pharmaceutical Name