Berin Plus

Generic

Vitamin B1, B6 & B12

Indications

Vitamin B1, B6, and B12 are used to treat vitamin B1, B6, and B12 deficient syndrome. It's also used to assist the treatment of neuritis and non-inflammatory nerve disorders including diabetic neuropathy.

• Neuralgin in the periphery
• Lumbago
• Myalgia
• Neuritis of the optic nerve
• Sciatica
• Facial neuralgia is a painful condition that affects the face.
• Neuralgia between the ribs
• Pain in the spine.

Pharmacology

Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes nerve health, improves mood, and strengthens the heart. Vitamin B6 forms red blood cells, helps cells produce protein, and produces neurotransmitters, for example. Serotonin and the release of stored forms of energy help prevent CVS disease and stroke, help relieve depression, and relieve insomnia. Vitamin B12 is essential for cell replication and for the production of red blood cells. It can prevent anemia, help prevent depression, relieve nerve pain, numbness, tingling and reduce the risk of heart disease.

Vitamins are well absorbed orally. It is widely distributed in most tissues and occurs in breast milk. In the cell, thiamine mainly exists in the form of diphosphate. The amount of thiamine stored in the body is not large, and the amount that exceeds the body's needs will be excreted in the urine in the form of unchanged thiamine or metabolites. Pyridoxine, pyridoxal and pyridoxamine are easily absorbed from the gastrointestinal tract after oral administration, and are converted into the active forms of pyridoxal phosphate and pyridoxamine phosphate. They are mainly stored in the liver, where they are oxidized to 4-pyridoxic acid and other inactive metabolites, and are excreted in the urine. As the dose increases, the amount of urine excreted in the original form increases proportionally.

Dosage & Administration

Tablet: 1-3 Tablets per day or as advised by the physician.

Injection:

• In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
• In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.

Use in children: There is no information on the use of this drug in children.

Contraindications

Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.

Side Effects

Although it is generally well tolerated, allergic responses have been reported in a few individuals.

Pregnancy & Lactation

Although oral tablet form is preferred, injection is not advised during pregnancy or breastfeeding owing to the presence of benzyl alcohol.

Precautions & Warnings

Cyanocobalamin should not be administered to individuals who have subacute spinal degeneration. Cyanocobalamin is not a good type of vitamin B12 for treating visual neuropathies caused by high cyanocobalamin levels in the blood.

Therapeutic Class

Specific combined vitamin preparations

Storage Conditions

Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.

Pharmaceutical Name

Glaxo Smithkline Bangladesh Limited