Cavir 0.5

Indications of Cavir 0.5 Tablet

Entecavir is used to treat compensatory liver disease, chronic hepatitis B virus infection in adults with evidence of viral replication and histologically documented active liver inflammation and fibrosis. It is also effective for decompensated cirrhosis.

 

Pharmacology of Cavir 0.5 Tablet

Entecavir is a nucleoside analogue of guanosine with potent and selective activity against HBV polymerase. For pharmacological action, it is phosphorylated in the active triphosphate (TP) form. Entecavir triphosphate inhibits the triple function of viral polymerase

• HBV polymerase primer,
• Reverse transcription of negative strand from messenger RNA
• Synthesis of positive strand of HBV DNA.

 

Dosage & Administration of Cavir 0.5 Tablet

Administration of Entecavir with food decreases absorption and so it should be taken in an empty stomach (at least 2 hours before or 2 hours after meal).

Adult over 16 years, not previously treated with nucleoside analogues: 0.5 mg once daily

Adult over 16 years with lamivudine or telbivudine resistant chronic hepatitis B: 1 mg once daily.

 

Interactions of Cavir 0.5 Tablet

Since entecavir is eliminated primarily by the kidneys, co-administration with drugs that reduce kidney function or that compete for active tubular secretion may increase serum concentrations of either drug.

 

Contraindications

Entecavir is contraindicated in patients with previously demonstrated hypersensitivity to Entecavir or any component of the product.

 

Side Effects of Cavir 0.5 Tablet

The most common side effects are headache, fatigue, dizziness and nausea.

 

Pregnancy & Lactation

Use in Pregnancy: There are no adequate and well-controlled studies in pregnant women. Entecavir should only be used during pregnancy if the benefit outweighs the potential risk to the fetus.

Use during lactation: It is not known whether entecavir is excreted in human milk. Mothers should be instructed not to breastfeed if they are taking entecavir.

 

Precautions & Warnings

Liver function tests are monitored every 3 months and hepatitis B virus and serological markers are monitored every 36 months. Stop if you have liver failure, fatty liver, progressive liver enlargement, or unexplained lactic acidosis. Stopping and recurrent hepatitis may occur.

 

Therapeutic Class

Hepatic viral infections (Hepatitis B)

 

Storage Conditions

Store at temperatures not above 30°C.

 

Pharmaceutical Name of Cavir 0.5 Tablet

Square Pharmaceuticals Ltd

 

Generic of Cavir 0.5 Tablet

Entecavir