Vir 0.5

Indications of Vir 0.5 Tablet

Entecavir is used to treat chronic hepatitis B virus infection in people who have compensated liver disease, evidence of viral replication, and active liver inflammation or fibrosis as shown by histology. It also helps people with decompensated cirrhosis.

 

Pharmacology of Vir 0.5 Tablet

Entecavir is a guanosine nucleoside analog that inhibits HBV polymerase in a strong and specific manner. It is phosphorylated to the active triphosphate (TP) form for pharmacological activity. Entecavir triphosphate inhibits all three actions of the viral polymerase: priming of the HBV polymerase, reverse transcription of the negative strand from pregenomic messenger RNA and reverse transcription of the positive strand from the pregenomic messenger RNA. The positive strand of HBV DNA is synthesized.

 

Dosage & Administration of Vir 0.5 Tablet

Entecavir absorption is reduced when taken with meals, hence it should be taken on an empty stomach (at least 2 hours before or 2 hours after a meal).

Adults over 16 years old who have never been treated with nucleoside analogs should take 0.5 mg once daily.

Adults over 16 years old with chronic hepatitis B who are resistant to lamivudine or telbivudine should take 1 mg once a day.

 

Interaction of Vir 0.5 Tablet

Coadministration with medications that decrease renal function or compete for active tubular secretion may increase serum concentrations of the either drug because Entecavir is primarily removed by the kidney.

 

Contraindications

Patients who have previously shown hypersensitivity to Entecavir or any component of the medicine should not use it.

 

Side Effects of Vir 0.5 Tablet

Headache, tiredness, dizziness, and nausea are the most prevalent adverse effects.

 

Pregnancy & Lactation

Pregnancy: No suitable and well-controlled trials have been conducted in pregnant women. Entecavir should only be given to a pregnant woman if the possible benefit outweighs the danger to the fetus.

Entecavir is not known to be excreted in human milk when used during breastfeeding. If a mother is using Entecavir, she should not breastfeed her child.

 

Precautions & Warnings

Every 3 months, check liver function tests, and every 3-6 months, check viral and serological markers for hepatitis B. If you notice a change in your liver function, hepatic steatosis, progressive hepatomegaly, or unexplained lactic acidosis, stop taking it. Discontinuation may result in recurrent hepatitis.

 

Therapeutic Class

Infections of the liver caused by viruses (Hepatitis B)

 

Storage Conditions

Temperatures should not exceed 30°C.

 

Pharmaceutical Name of Vir 0.5 Tablet

ACME Laboratories Ltd

 

Generic of Vir 0.5 Tablet

Entecavir