Cefracef 500

Indications of Cefracef 500

Cephradine is indicated for the treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria. These include-

• Undesirable Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngotracheobronchitis, and otitis media, and also
• Lower respiratory tract infections: bronchitis (acute and chronic), lobar pneumonia and bronchopneumonia.
• Urinary tract infections: cystitis, urethritis and pyelonephritis.
• Skin and soft tissue infections: abscess, cellulitis, furunculosis and impetigo.

The following microorganisms are susceptible, in vitro to Cephradine:

• Gram-positive: Staphylococci (both penicillin-sensitive and resistant strains and penicillinase-producing species), Streptococci, Streptococci pyogenes (beta-hemolytic), Streptococcus pneumonia.
• Gram-negative: Escherichia coli, Klebsiella spp, Proteus mirabilis, Haemophilus influenza, Shigella spp, Salmonella spp (including Salmonella typhi), Neisseria spp Many strains of E. coli and Staphylococcus aureus that produce the enzyme penicillinase and thus are ampicillin-resistant, are susceptible to Cephradine which is unaffected by this enzyme.

 

Pharmaceutical Name of Cefracef 500

NIPRO JMI Pharma Ltd.

 

Pharmacology

Cephradine may be a semisynthetic wide range bactericidal anti-microbial, it is dynamic against contaminations caused by both gram-positive and gram-negative microorganisms. Both penicillinases creating and nonproducing staphylococci are touchy to Cephradine. The most location of activity of Cephradine is the cell divider of microscopic organisms. Cell divider of delicate life-form contains peptidoglycan. Cephradine hinders cross-linking handle and as a result cell divider with numerous pores is shaped, in this way lysis of microbes happen due to outside osmotic weight.

 

Dosage & Administration

For oral administration-
Adults:

• Urinary tract infections: 500mg four times daily or 1g twice daily. Infections which are severe or chronic may necessitate the administration of higher doses. Where complications arise including prostatitis and epididymitis continued intensive treatment is required.
• Respiratory tract infections: 250 to 500mg four times daily or 500mg to 1g twice daily, dependent on the site and severity of the infection.
• Skin and soft tissue infections: 250 to 500mg four times daily or 500mg to 1g twice daily, again dependent on the site and severity of the infection.

Children:

• Total daily dose of 25 to 50mg/kg given in two or four equally divided doses.
• Otitis media: Total daily dose of 75 to 100mg/kg given in divided doses 6 to 12 hourly.
• Maximum daily dosage: 4 gm

Elderly: The normal adult dose is appropriate. Patients with impaired renal or hepatic function should be monitored during treatment.

For injectable administration-

• Adult: The usual dose is 2-4 gm daily in four equally divided doses up to 8 gm daily. For prophylaxis a single preoperative dose of 1-2 gm intramuscularly or intravenously is given.
• Children: The dose is 50-100 mg/kg daily in four equally divided doses, up to 300 mg/kg daily in severe infection.

 

Interaction of Cefracef 500

When nephrotoxic medications like aminoglycosides are taken with Cefradine, the risk of kidney damage increases. Renal toxicity was increased by diuretics (e.g., frusemide, ethacrynic acid) and probenecid.

 

Contraindications

Cephradine ought to not be utilized in patients with known or suspected touchiness to cephalosporins.

 

Side Effects of Cefracef 500

Limited essentially to gastro-intestinal disturbances and on occasions to hypersensitivity phenomena. The latter is more likely to occur in individuals, who have previously demonstrated hypersensitivity and those with a history of allergy, asthma, hay fever, or urticaria. Skin reactions have occasionally been reported. Rare- Glossitis, heartburn, dizziness, tightness in the chest, nausea, vomiting, diarrhea, abdominal pain, vaginitis, candida overgrowth. Skin and hypersensitivity reactions include urticaria, skin rashes, joint pains, edema.

• Blood and lymphatic system disorders- Unknown: blood disorders (including thrombocytopenia, leucopenia, agranulocytosis, aplastic anemia and haemolytic anemia)
• Immune system disorders- Unknown: Fever, serum sickness-like reactions, anaphylaxis
• Psychiatric disorders- Unknown: Confusion, sleep disturbances
• Nervous system disorders- Unknown: hyperactivity, hypertonia, dizziness, nervousness; Rarely: Headache
• Hepatobiliary disorders- Frequency unknown: Liver, enzyme disturbances, transient hepatitis, cholestatic jaundice
• Renal and urinary disorders- Unknown: Reversible interstitial nephritis
• Investigations- Unknown: Elevation of blood urea nitrogen, serum creatinine, alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase.

 

Pregnancy & Lactation

In spite of the fact that creature ponders have not illustrated any teratogenicity, security in pregnancy has not been set up. Cephradine is excreted in breast drain and ought to be utilized with caution in lactating moms. Since the pharmaceutical may cause discombobulation, patients ought to be cautioned around working perilous apparatus, counting automobiles.

 

Precautions & Warnings

• Prolonged use of an anti-infective may result in the development of superinfection due to the emergence of resistant organisms.
• Cephradine should be administered with care to patients hypersensitive to penicillins because of the risk of cross-sensitivity between beta-lactam antibiotics.
• Cephalosporin antibiotics may cause a positive result in Coombs’ testing. When Coombs testing is performed on neonates whose mothers received cephalosporins prior to labor, it should be noted that a positive result may be due to the drug.
• Cephradine may cause a false positive urine glucose result when Benedict’s or Fehling’s solutions or tablets such as Clinitest are used in the testing. This does not occur with enzyme-based tests (e.g., Clinistix, Diastix).
• Dosage adjustment is necessary for renal impairment.
• This product contains lactose. Patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicine.

 

Therapeutic Class

Cephalosporins of the first generation.

 

Storage Conditions

Cephradine Suspension ought to be naturally arranged. Reconstituted Suspension ought to be utilized inside 7 days in the event that kept at room temperature or inside 14 days, in the event that kept in a fridge. Cephradine Infusion arrangements ought to be utilized within 2 hours when kept at room temperature. When put away at 5°C, arrangements hold power for 12 hours. Reconstituted arrangements may shift in color from light to straw yellow; in any case, this does not influence the strength. Don't utilize afterward than the date of expiry. Keep all medications out of the reach of children. To be apportioned as it were on the medicine of an enlisted doctor.

 

Generic of Cefracef 500

Cephradine