Cholcut 10

Generic

Rosuvastatin

 

Indications

Heterozygous Hypercholesterolemia (Familial and Non familial)

 

Pharmacology

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol.

 

Dosage & Administration

Rosuvastatin can be taken with or without food, at any time of day.

 

Interaction

 Combination increases Rosuvastatin exposure. Rosuvastatin dose should be limited to 5 mg once daily.

 

Contraindications

Known hypersensitivity to product components

Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels

Pregnant women and women who may become pregnant.

 

Side Effects

Rosuvastatin is generally well tolerated. The most frequent adverse events thought to be related to Rosuvastatin were headache, myalgia, constipation, asthenia, abdominal pain and nausea.

 

Pregnancy & Lactation

The safety in pregnant women has not been established. It is not known whether Rosuvastatin is excreted in human milk or not.

 

Precautions & Warnings

isks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs.

 

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins

 

Storage Conditions

Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.

 

Pharmaceutical Name

Ziska Pharmaceuticals Ltd.