Coxsafe 90

Indications of Coxsafe 90

Etoricoxib is indicated for relief of pain and inflammation in Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Acute Gout, Primary Dysmenorrhoea, Postoperative Dental Pain & other Chronic Musculoskeletal Disorders.

 

Pharmaceutical Name of Coxsafe 90

Sharif Pharmaceuticals Ltd

 

Pharmacology

Etoricoxib is a Nonsteroidal Anti-inflammatory Drug (NSAID) that exhibits anti[1]inflammatory, analgesic and antipyretic activities. It is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation and fever. Selective inhibition of COX-2 by Etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelets function.

 

Dosage & Administration

Adult and adolescent (over 12 years):

Osteoarthritis & Chronic Musculoskeletal Disorders: 60 mg once daily Rheumatoid Arthritis, Ankylosing Spondylitis & Postoperative Dental Pain: 90 mg once daily

Primary Dysmenorrhoea & Acute Gout: 120 mg once daily Safety and effectiveness of Etoricoxib in paediatric patients have not been established. Or as directed by physician.

 

Interaction of Coxsafe 90

Oral anticoagulants, Diuretics, ACE inhibitors, Acetylsalicylic acid, Cyclosporin, Tacrolimus, Lithium, Birth control pills, Prednisone/Prednisolone, Digoxin, Ketoconazole, Rifampicin and Antacids have interaction with Etoricoxib.

 

Contraindications

Etoricoxib is contraindicated to patients with known hypersensitivity to Etoricoxib or to any of the excipients of this medicinal product. Etoricoxib is also contraindicated to patients with active peptic ulceration or gastro[1]intestinal (GI) bleeding, severe hepatic dysfunction; patient having inflammatory bowel disease and severe congestive heart failure; children and adolescents under 16 years of age.

 

Side effects of Coxsafe 90

Dry mouth, taste disturbance, mouth ulcers, constipation, flatulence, appetite and weight changes, chest pain, paraesthesia, fatigue, influenza-like syndrome & myalgia.

 

Pregnancy and Lactation

It should be used during the first two trimesters of pregnancy only if the potential benefit justifies the potential risk to the foetus. It is not known whether this drug is excreted in human milk.

 

Precautions and warnings

Decreased kidney function and liver function, dehydration, hypertension, history of heart failure, perforation and people over 65 years of age.

 

Therapeutic Class

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

 

Storage Conditions

Store in a cool and dry place, protected from light. Keep out of reach of children.

 

Generic of Coxsafe 90

Etoricoxib