Docopa 400

Indications of Docopa 400

Doxophylline is used to treat asthma, COPD and bronchospasm.

 

Pharmaceutical Name of Docopa 400

Aristopharma Ltd.

 

Pharmacology

The drug doxophylline is a brand-new bronchodilator. The inclusion of a dioxolane group in position 7 distinguishes it from Theophylline structurally. Doxophylline relaxes bronchial smooth muscle by inhibiting phosphodiesterase 4 specifically. Doxophylline, unlike Theophylline, appears to have lower affinity for adenosine A1 and A2 receptors, which could account for the drug's improved safety profile. Doxophylline has been shown to suppress platelet activating factor (PAF) production as well as the creation of leukotrienes.

 

Dosage and Administration

Elderly: 200 mg tablet two or three times daily.

Adults: 400 mg tablet two or three times daily or as prescribed by the physician.

Children:

>12 years of age: 10 ml syrup or 200 mg tablet two or three times daily.

6-12 years of age: 6-9 mg/kg body weight two times daily, i.e. if body weight is 10 kg, 3 ml (60 mg) two times daily or as prescribed by the physician.

If required daily dose of Doxophylline is 400 mg then Doxophylline SR tablet to be taken once daily or as prescribed by the physician

 

Interaction of Docopa 400

The drug doxophylline is a brand-new bronchodilator. The inclusion of a dioxolane group in position 7 distinguishes it from Theophylline structurally. Doxophylline relaxes bronchial smooth muscle by inhibiting phosphodiesterase 4 specifically. Doxophylline, unlike Theophylline, appears to have lower affinity for adenosine A1 and A2 receptors, which could account for the drug's improved safety profile. Doxophylline has been shown to suppress platelet activating factor (PAF) production as well as the creation of leukotrienes.

 

Contraindications

Doxophylline is contraindicated in acute myocardial infarction. It is also contraindicated in patients with hypotension, in lactating women & patients who have shown hypersensitivity to its components.

 

Side Effects of Docopa 400

Doxophylline seldom produces major adverse effects, however it can have the same consequences as taking too much coffee. Nausea, vomiting, headaches, upset stomach, and heartburn are some of the symptoms.

 

Pregnancy & Lactation

Animal reproduction studies show that doxophylline has no effect on reproduction capacity or causes fetal harm when given to pregnant animals. However, because there is minimal experience with xanthines during pregnancy in humans, they should only be given to pregnant women if absolutely necessary. Doxophylline should not be taken by breastfeeding mothers.

 

Precautions & Warnings

A number of known variables influence the half-life of xanthine derivatives. Patients with liver illness, congestive heart failure, and those on certain other treatments such as erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propanolol, and anti-flu vaccine may experience a delay. In these circumstances, a lower Doxophylline dose may be required. Smoking, phenytoin, and other anticonvulsants may cause an increase in clearance and a shorter mean half-life. In these circumstances, greater Doxophylline doses may be required.

 

Therapeutic Class

Bronchodilator, Methyl xanthine derivatives

 

Storage Conditions

Keep away from light and heat in a dry location. Keep out of children's reach. Doxophylline should only be used if a specialist physician has prescribed it.

 

Generic of Docopa 400

Doxophylline