Doxoma 400

Indications of Doxoma 400

Asthma, COPD, and bronchospasm are all treated with doxophylline.

 

Pharmaceutical Name of Doxoma 400

Drug International Ltd.

 

Pharmacology

The drug doxophylline is a brand-new bronchodilator. The inclusion of a dioxolane group in position 7 distinguishes it from Theophylline structurally. Doxophylline relaxes bronchial smooth muscle by inhibiting phosphodiesterase 4 specifically. Doxophylline, unlike Theophylline, appears to have a lower affinity for adenosine A1 and A2 receptors, which could account for its improved safety.

 

Dosage & Administration

Elderly: 200 mg tablet two or three times daily.

Adults: 400 mg tablet two or three times daily or as prescribed by the physician.

Children:

• >12 years of age: 10 ml syrup or 200 mg tablet two or three times daily.
• 6-12 years of age: 6-9 mg/kg body weight two times daily, i.e., if bodyweight is 10 kg, 3 ml (60 mg) two times daily or as prescribed by the physician.

If the required daily dose of Doxophylline is 400 mg then Doxophylline SR tablet is to be taken once daily or as prescribed by the physician.

 

Interaction of Doxoma 400

Doxophylline ought to not be managed in conjunction with other xanthine subordinates. Poisonous synergism with ephedrine has been archived for xanthines. Like other xanthine’s, concomitant treatment with troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and anti-flu antibody may diminish the hepatic clearance of xanthine’s causing an increment in blood levels. No, prove of a relationship between Doxophylline serum concentrations and poisonous occasions has been detailed.

 

Contraindications

In acute myocardial infarction, doxophylline is contraindicated. Individuals with hypotension, nursing women, and patients who have exhibited allergy to its components are also advised against using it.

 

Side Effects of Doxoma 400

Doxophylline seldom produces major adverse effects, however, it can have the same consequences as taking too much coffee. Nausea, vomiting, headaches, upset stomach, and heartburn are some of the symptoms.

 

Pregnancy & Lactation

Creature propagation thinks about shows that Doxophylline does not cause fetal hurt when managed by pregnant creatures or cannot influence generation capacity. Be that as it may, since there's a restricted encounter in people amid pregnancy, xanthines ought to be given to pregnant ladies as it were on the off chance that clearly required. Doxophylline is contraindicated in nursing moms.

 

Precautions & Warnings

The half-life of xanthine subsidiaries is impacted by a number of known factors. It may be delayed in patients with liver illness, in patients with congestive heart disappointment, and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, and anti-flu antibody. In these cases, a lower measurement of Doxophylline may be required. Phenytoin, other anticonvulsants, and smoking may cause an increment in clearance with a shorter cruel half-life. In these cases, higher dosages of Doxophylline may be required.

 

Therapeutic Class

Methylxanthine derivatives, bronchodilator.

 

Storage Conditions

Store in a cool & dry place, protected from light.

 

Generic of Doxoma 400

Doxophylline.