Doxoven 400

Indications of Doxoven 400

Asthma, COPD, and bronchospasm are all treated with doxophylline.

 

Pharmaceutical Name of Doxoven 400

Pharmacology

The drug doxophylline is a brand-new bronchodilator. The presence of a dioxolane group in position 7 distinguishes it from Theophylline structurally. Doxophylline relaxes bronchial smooth muscle by inhibiting phosphodiesterase 4 selectively. Doxophylline, on the other hand, appears to have lower affinities for adenosine A1 and A2 receptors than Theophylline.

 

Administration & Dosage

If a daily dose of 400 mg of Doxophylline is required, the Doxophylline SR tablet should be taken once daily or as directed by a physician.

 

Interaction of Doxoven 400

Other xanthine derivatives should not be taken together with doxophylline. Xanthines have been shown to have toxic synergism with ephedrine. Concomitant therapy with troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and anti-flu vaccine, as with other xanthines, may reduce xanthine hepatic clearance, resulting in an increase in blood levels.

 

Contraindications

In acute myocardial infarction, doxophylline is contraindicated. Patients with hypotension, lactating women, and patients who have shown hypersensitivity to its components are also advised against taking it.

 

Side Effect of Doxoven 400

Doxophylline rarely causes serious side effects, but it can have the same effects as taking too much caffeine. Nausea, vomiting, headaches, upset stomach, and heartburn are some of the symptoms.

 

Pregnancy & Lactation

Animal reproduction studies show that doxophylline has no effect on reproduction capacity or causes fetal harm when given to pregnant animals. However, because there is limited experience with xanthines during pregnancy in humans, they should only be given to pregnant women if absolutely necessary. Doxophylline should not be taken by nursing mothers.

 

Precautions & Warnings

A number of known variables influence the half-life of xanthine derivatives. Patients with liver disease, congestive heart failure, and those taking certain other drugs such as erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propanolol, and anti-flu vaccine may experience a delay. In these cases, a lower Doxophylline dose may be required.

 

Therapeutic Class

Methylxanthine derivatives, bronchodilator

 

Storage Conditions

Store below 30°C, away from light, in a cool, dry place. Keep out of children's reach.