Enigma 100

Generic

Sildenafil Citrate

 

Indication

Adegra is indicated for the treatment erectile dysfunction in men.

 

Pharmacology

Sildenafil is a selective inhibitor of cyclic Guanosine Monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) used for treatment of erectile dysfunction.Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that inhibits the cyclic Guanosine Monophosphate phosphodiesterase (cGMP). It's a medication that's used to treat erectile dysfunction.

 

Dosage 

The recommended dose of Sildenafil is 50 mg taken approximately 1 hour before sexual activity. However, Sildenafil may be taken anywhere from half an hour to 4 hours before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

 

Administration

Sildenafil may takes longer time to work if you take it with a heavy meal.

 

Interaction

When Sildenafil is taken with organic nitrates for angina, it can cause hypotension. Cimetidine, a drug used to treat gastric ulcers, as well as certain antibiotics like Erythromycin and Rifampicin, and protease inhibitors like Ritonavir and Saquinavir used to treat HIV infection, may raise Sildenafil levels in the blood. Ketoconazole and Itraconazole, both of which are used to treat fungal infections, may impair Sildenafil clearance.

 

Contraindications

Any component of sildenafil is contraindicated in patients who are hypersensitive to it. Sildenafil enhances the hypotensive effects of nitrates, hence it's not recommended for people who take organic nitrates on a regular or irregular basis.

 

 Side effects

The side-effects of Sildenafil include dyspepsia, nausea, vomiting, headache (including migraine), flushing, dizziness, myalgia, back pain, visual disturbances (non-arteritic anterior ischaemic optic neuropathy has been reported. Drug should be stopped if sudden visual impairment occurs) and nasal congestion. Less common side-effects include painful red eyes, palpitation, tachycardia, hypo/hypertension and epistaxis. Other side-effects reported rarely include syncope, hypersensitivity reactions (including rash, facial oedema, and Stevens-Johnson syndrome) and priapism. Serious cardiovascular events (including arrhythmia, unstable angina, and myocardial infarction), seizures, sudden hearing loss and retinal vascular occlusion have also been reported.

 

 Pregnancy and Lactation

Adegra is not indicated for use by women. Special considerations for patients with kidney or liver problems Patients with kidney or liver problems should start with a lower dose (25mg).

 

Precautions & Warnings

Patients with allergies to other drugs or other substances such as foods, preservatives, or dyes, heart or blood vessel disorders, or sudden loss of vision in one or both eyes should be cautious. Patients with diabetes, kidney or liver problems, leukemia, multiple myeloma, any disease or deformity of the penis, any bleeding disorder such as haemophilia, stomach ulcer, sickle cell anemia, color vision problems, sudden decrease or loss of hearing, or receiving any other treatment for impotence should exercise caution.

 

Therapeutic Class

Erectile Dysfunction Drugs

 

Storage Conditions

Headache, flushing, dyspepsia, nasal congestion, urinary tract infection, altered eyesight, diarrhea, dizziness, and rash are all side effects of Sildenafil.

 

Pharmaceutical Name