Expres 5

Indications of Expres 5 Tablet 

The use of escitalopram oxalate in the treatment of major depressive episodes is recommended.

Treatment for panic disorder that includes or excludes agoraphobia.

Social anxiety disorder treatment (social phobia).

Generalized anxiety disorder (GAD) is treated.

Obsessive-compulsive disorder treatment.

 

Pharmacology of Expres 5 Tablet

Escitalopram is a selective serotonin reuptake inhibitor that is used orally (SSRI). The pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram is escitalopram. When it comes to inhibiting 5-HT reuptake, escitalopram is at least 100 times more effective than the R-enantiomer. Escitalopram has no or poor affinity for serotonergic and other receptors, such as alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic, and benzodiazepine receptors.

 

Dosage & Administration of Expres 5 Tablet

Safety of daily doses above 20 mg has not been demonstrated. Escitalopram Oxalate is administered as a single daily dose and may be taken with or without food.

Major depressive episodes: Usual dosage is 10 mg once daily. Depending on individual patient response, the dose may be increased to a maximum of 20 mg daily. Usually, 2-4 weeks are necessary to obtain an antidepressant response. After the symptoms resolve, treatment for at least 6 months is required for consolidation of the response.

Panic disorder with or without agoraphobia: An initial dose of 5 mg is recommended for the first week before increasing the dose to 10 mg daily. The dose may be further increased, up to a maximum of 20 mg daily, dependent on individual patient response. Maximum effectiveness is reached after about 3 months. The treatment lasts several months.

Social anxiety disorder: Usual dosage is 10 mg once daily. Usually, 2-4 weeks are necessary to obtain symptom relief. The dose may subsequently, depending on individual patient response, be decreased to 5 mg or increased to a maximum of 20 mg daily. Social anxiety disorder is a disease with a chronic course, and treatment for 12 weeks is recommended to consolidate response. Long-term treatment of responders has been studied for 6 months and can be considered on an individual basis to prevent relapse; treatment benefits should be re-evaluated at regular intervals. Social anxiety disorder is a well-defined diagnostic terminology of a specific disorder, which should not be confounded with excessive shyness. Pharmacotherapy is only indicated if the disorder interferes significantly with professional and social activities. The place of this treatment compared to cognitive behavioural therapy has not been assessed. Pharmacotherapy is part of an overall therapeutic strategy.

Generalised anxiety disorder: Initial dosage is 10 mg once daily. Depending on the individual patient response, the dose may be increased to a maximum of 20 mg daily. Long term treatment of responders has been studied for at least 6 months in patients receiving 20 mg/day. Treatment benefits and dose should be re-evaluated at regular intervals.

Obsessive-Compulsive Disorder: Initial dosage is 10 mg once daily. Depending on the individual patient response, the dose may be increased to a maximum of 20 mg daily. As OCD is a chronic disease, patients should be treated for a sufficient period to ensure that they are symptom-free. Treatment benefits and dose should be re-evaluated at regular intervals.

 

Interaction of Expres 5 Tablet

Antidepressants such as SSRIs and related antidepressants should not be begun for at least two weeks after quitting an MAOI. An MAOI, on the other hand, should not be taken until at least one week after an SSRI or similar antidepressant has been discontinued (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine).

 

Contraindications

Escitalopram is not recommended for patients who have a known hypersensitivity to Escitalopram, Citalopram, or any of the drug's inactive components. It's not a good idea to take escitalopram and monoamine oxidase/pimozide at the same time.

 

Side Effects of Expres 5 Tablet

SSRIs are less calming and have less antimuscarinic and cardiotoxic impacts than tricyclic antidepressants. Side-effects of the SSRIs incorporate gastrointestinal impacts (dose-related and reasonably common incorporate queasiness, heaving, dyspepsia, stomach torment, the runs, obstruction), anorexia with weight misfortune (expanded craving and weight pick up too detailed) and extreme touchiness responses counting hasty, urticaria, angioedema, anaphylaxis, arthralgia, myalgia, and photosensitivity; other side-effects incorporate dry mouth, anxiety, uneasiness, migraine, sleep deprivation, tremor, tipsiness, asthenia, visualizations, tiredness, shakings, galactorrhoea, sexual brokenness, urinary maintenance, sweating, hypomania or madness, development disarranges and dyskinesias, visual disturbances.

 

Pregnancy & Lactation

The hazards and advantages of treating a pregnant woman with Escitalopram throughout the third trimester should be carefully considered by the physician. It's passed through human breast milk. The risk of citalopram exposure for the newborn and the benefits of Escitalopram medication for the mother should be considered when deciding whether to continue or stop nursing or Escitalopram therapy.

 

Precautions & Warnings

SSRIs should be used with caution in patients with epilepsy (avoid if poorly controlled, discontinue if convulsions develop), concurrent electroconvulsive therapy (prolonged seizures have been reported with fluoxetine), history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase bleeding risk, and history of bleeding disorders (especially gastro-intestinal bleeding).

 

Therapeutic Class

SSRIs & related anti-depressant drugs

 

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.

 

Pharmaceutical Name of Expres 5 Tablet

Sanofi Bangladesh Ltd

 

Generic of Expres 5 Tablet