Feluric 40

Generic

Febuxostat

 

Indications

Febuxostat is used to treat hyperuricemia in gout patients on a long-term basis. Febuxostat is not indicated for asymptomatic hyperuricemia therapy.

 

Pharmacology

Febuxostat is a selective xanthine oxidase (XO) inhibitor that is non-purine. It lowers blood uric acid levels by blocking the enzyme xanthine oxidase, which produces uric acid. Xanthine oxidase converts hypoxanthine to xanthine, which is then converted to uric acid. At therapeutic doses, Febuxostat is unlikely to inhibit other enzymes involved in purine and pyrimidine production and metabolism.

 

Dosage & Administration

Febuxostat is recommended at 40 mg or 80 mg once daily. The recommended starting dose of Febuxostat is 40 mg once daily. For patients who do not achieve a serum uric acid less than 6 mg /dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended. Febuxostat can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Febuxostat to patients with mild to moderate renal or hepatic impairment.

 

Interaction

Rupatadine should be taken with caution in individuals who have a known QT interval prolongation, uncorrected hypokalemia, or continuing proarrhythmic circumstances such clinically severe bradycardia or acute myocardial ischemia. In senior individuals, rupatadine should be administered with care (65 years and older). The use of Rupatadine 10 mg tablets in patients with compromised renal or liver function is currently not indicated due to a lack of clinical data.

 

Contraindications

Febuxostat is not recommended for those who are using azathioprine, mercaptopurine, or theophylline.

 

Side Effect

Liver function problems, nausea, arthralgia, and rash are the most frequent side effects linked with the usage of Febuxostat.

 

Pregnancy & Lactation

Pregnancy Classification C. In pregnant women, there are no appropriate and well-controlled trials. Only if the possible benefit outweighs the danger to the fetus should Febuxostat be taken during pregnancy. This medication is not known to be excreted in human milk. When given to a breastfeeding mother, Febuxostat should be used with caution.

 

Precautions & Warnings

Due to the emergence of drug-resistant microorganisms, prolonged use of anti-infectives can lead to the development of superinfections.

Cephradine should be used with caution in patients allergic to penicillin, due to the risk of cross allergies between beta-lactam antibiotics.

Cephalosporin antibiotics can cause a positive Coombs test. When performing the Coombs test in newborns whose mothers received cephalosporin treatment before delivery, it should be noted that the positive result may be due to the drug.

The use of Benedict or Fehling solutions or tablets (such as Clintest) in the cephradine test may cause false positive urine glucose results. This does not happen in enzyme-based tests (eg Clinistix, Diastix).

Dosage should be adjusted in renal impairment.

This product contains lactose. Patients with rare genetic problems such as galactose intolerance, Lapp lactase deficiency, or glucose or galactose malabsorption should not take this medicine.

 

Therapeutic Class

Drugs used in Gout

 

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

 

Pharmaceutical Name

Healthcare Pharmaceuticals Ltd.