Gestrenol 5

Indications of Gestrenol 5

Gestrenol 5 is indicated in:

• Habitual abortion
• Threatened premature delivery
• Intra Uterine Growth Retardation (IUGR)
• Threatened abortion

 

Pharmaceutical Name

Renata Limited

 

Pharmacology

Synthetic progesterone derivative allylestrenol is used to treat threatening pregnancies. It can help women avoid early labor and give birth to a healthy newborn. It stimulates the secretory phase in myometrium, creates conditions for development of fertilized ovum. It has a tocolytic effect; reduces sensitivity of myometrium to oxytocin. It stimulates the development of acinus of mammary glands, secretory activity of trophoblasts, and development of aldosterone by adrenal glands. Allylestrenol also has a selection of β-adrenergic effect. As a result, it increases the production of placental hormones by stimulating the synthesis of placental progesterone in the body.

 

Dosage & Administration of Gestrenol 5

• Threatened abortion: 1 tablet three times daily until symptoms disappear.
• Habitual abortion: 1-2 tablets daily as soon as pregnancy is diagnosed. The administration should be continued for at least one month after the end of the critical period.
• Intra Uterine Growth Retardation: 1 tablet three times a day at least two months. Dose to be reduced if symptoms improve.
• Threatened premature delivery: Dosage must be determined individually. High dosages (up to 40 mg daily) have been used.

In case of a missed dose, it should be taken as soon as the patient remembers & she should continue the regular dosing schedule. A double dose is not recommended.

 

Interactions of Gestrenol 5

The effects of Gestrenol Tablet may alter if you take other medications or over-the-counter remedies at the same time. This could make you more susceptible to negative effects or cause your medication to stop working effectively. Tell your doctor about all of your medications, vitamins, and herbal supplements so that he or she can help you avoid or manage drug interactions.

Gestrenol Tablet may interact with the following drugs and products:

• Carbamazepine
• Griseofulvin
• Ketoconazole
• Phenobarbital
• Phenytoin
• Rifampin

 

Contraindications

Cerebral apoplexy, as a diagnostic test for pregnancy; severe hepatic impairment, Hypersensitivity; thrombophlebitis; undiagnosed vaginal bleeding, incomplete abortion, hormone-dependent carcinoma.

 

Side-Effects of Gestrenol 5

Treatment with Allylestrenol (especially a long term treatment) is known to cause some gastrointestinal complaints such as vomiting, nausea, and sometimes epigastric discomfort.

 

Pregnancy & Lactation

Allylestrenol is specifically designed to be taken during pregnancy. It should be discontinued after delivery as it may affect a nursing infant to a small but noticeable degree.

 

Precautions & Warnings

Patients with the following conditions should be cautious: Heart disease, congestive heart failure, sick sinus syndrome, coronary artery disease, seizures, epilepsy, renal dysfunction, migraine headaches, or breathing diseases including asthma, emphysema, chronic bronchitis, or COPD, breast-feeding.

 

Therapeutic Class

Female Sex hormones

 

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

 

Generic Name of Gestrenol 5

Allylestrenol

 

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