L-Cardin 2

Generic

Lacidipine

 

Indications

Lacidipine is indicated for the treatment of hypertension either alone or in combination with other antihypertensive agents, including ß-blockers, diuretics, ACE-inhibitors, etc.

 

Pharmacology

Lacidipine hinders the convergence of calcium into smooth muscle cells by the competitive restraint of voltage-dependent calcium 'L' channels. This activity comes about within the hindrance of the impacts activated by the deluge of calcium into the cells, such as the enactment of the contractile proteins in smooth muscle.

 

Dosage & Administration

The recommended initial dose of Lacidipine is 2 mg once daily. The dose may be increased to 4 mg and then, if necessary, to 6 mg after 3 to 4 weeks. Lacidipine should be taken preferably in the morning.

 

Interaction

Lacidipine plasma concentrations can be boosted by taking cimetidine at the same time. In investigations using common antihypertensive drugs, as well as digoxin, tolbutamide, and warfarin, no significant pharmacodynamic interaction issues were discovered.

 

Contraindications

Touchiness to any fixing of this item, cardiogenic stun, unsteady angina, aortic stenosis, maintain a strategic distance from inside 1 month of myocardial localized necrosis, disabled cleared out ventricular work.

 

Side Effect

Lacidipine is generally well tolerated. Some individuals may experience minor side effects like flushing, palpitation, edema, headache, dizziness, rarely gastrointestinal disturbances, gum hyperplasia, mood disturbances, asthenia, polyuria, muscle cramps, skin rash, etc.

 

Pregnancy & Lactation

Pregnancy: There is no information on the security of Lacidipine in human pregnancy. Lacidipine gives no proof of a teratogenic impact in creature study.

Lactation: Drain exchange ponders in creatures have appeared that Lacidipine (or its metabolites) are likely to be excreted into breast drain. There's, in any case, no clinical encounter of Lacidipine in pregnancy and lactation. In like manner, Lacidipine ought to not be utilized amid pregnancy or lactation.

 

Precautions & Warnings

Abnormal cardiac conduction, low cardiac reserves, hepatic impairment; discontinue if ischemia discomfort begins soon after starting medication or if cardiogenic shock develops; avoid grapefruit juice.

 

Therapeutic Class

Calcium channel blockers are drugs that block calcium channels in the body.

 

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

 

Pharmaceutical Name

Drug International Ltd.